THE MOLECULAR CONTROL OF PROLIFERATION AND DIFFERENTIATION IN HEMATOPOIETIC-CELLS
- Author(s)
- Metcalf, D;
- Details
- Publication Year 1993-09,Volume 316,Issue #9,Page 866-870
- Journal Title
- COMPTES RENDUS DE L ACADEMIE DES SCIENCES SERIE III-SCIENCES DE LA VIE-LIFE SCIENCES
- Publication Type
- Journal Article
- Abstract
- The control of granulocyte and macrophage formation and function offers many insights into the developmental processes involved in hemopoiesis. Regulation of granulocyte and macrophage populations is mainly controlled by the actions of four glycoprotein regulators - the colony stimulating factors. These factors exhibit some redundancy in their actions but each is capable of regulating multiple events in the production, differentiation commitment, maturation and functional activities of the cells. The design of this regulatory system is such that it can ensure precise cell production under basal conditions but is also able to achieve large variations in cell production in response to emergency situations.
- Publisher
- JOHN LIBBEY EUROTEXT LTD
- Keywords
- COLONY-STIMULATING FACTOR; HEMATOPOIETIC STEM-CELLS; GM-CSF; GRANULOCYTE; RECEPTORS; COMMITMENT; RESPONSES; LECTURE; MICE
- Terms of Use/Rights Notice
- Refer to copyright notice on published article.
Creation Date: 1993-09-01 12:00:00