THE S-ANTIGEN OF PLASMODIUM-FALCIPARUM - REPERTOIRE AND ORIGIN OF DIVERSITY
- Author(s)
- BICKLE, Q; Anders, RF; Day, K; Coppel, RL;
- Details
- Publication Year 1993-10,Volume 61,Issue #2,Page 189-196
- Journal Title
- MOLECULAR AND BIOCHEMICAL PARASITOLOGY
- Publication Type
- Journal Article
- Abstract
- S-antigens are heat-stable, highly polymorphic proteins released by Plasmodium falciparum at the time of schizont rupture. Previously determined S-antigen sequences allowed the proposal of a general gene structure consisting of 5 sequence blocks. The sequence of the central block of tandem repeats provides a useful means of distinguishing the S-antigen allele and also its serotype, whereas the amino and carboxy terminal sequences defined the S-antigen family, 4 of which have been described. We present the sequence of 3 new S-antigen alleles, for the isolates HB3, KF1916 and KF1917. The allele-defining repeat sequence is ETGPGKAGEQG for HB3, GDQTEGS(S/A)GGK for KF1917 and AGSNE(E/K) for KF1916. The sequences of these newly described S-antigens are consistent with the proposed general gene structure and all belong to defined families, although carboxy-terminal sequences appear to be much more variable within a family than previously realised.
- Publisher
- ELSEVIER SCIENCE BV
- Keywords
- SEQUENCE; GENE; MALARIA; SEROTYPE; CONTAINS
- Publisher's Version
- https://doi.org/10.1016/0166-6851(93)90065-6
- Terms of Use/Rights Notice
- Refer to copyright notice on published article.
Creation Date: 1993-10-01 12:00:00