THYMIC DENDRITIC CELLS AND T-CELLS DEVELOP SIMULTANEOUSLY IN THE THYMUS FROM A COMMON PRECURSOR POPULATION
- Author(s)
- ARDAVIN, C; Wu, L; Li, CL; Shortman, K;
- Details
- Publication Year 1993-04-22,Volume 362,Issue #6422,Page 761-763
- Journal Title
- NATURE
- Publication Type
- Journal Article
- Abstract
- DENDRITIC cells, a minor cell population in lymphoid tissues, are specialized for presentation of antigenic peptides to T lymphocytes1. Thymic dendritic cells are involved in the deletion of self-reactive T lymphocytes2,3. Although all dendritic cells are ultimately of bone-marrow origin4-7, it has not been clear whether thymic dendritic cells are produced in the adult thymus from a precursor cell or whether they migrate there preformed from the periphery. Recently we isolated from adult mouse thymus a population of early T precursors that could still form B lymphocytes, but not erythroid or myeloid cells, when transferred intravenously8,9. Here we show that these thymic lymphoid precursor cells, as well as bone-marrow haematopoietic stem cells, are able to form both dendritic cells and T-cell progeny when transferred into an irradiated thymus. Such linked development may ensure that developing T cells are negatively selected predominantly by self antigens presented on newly formed thymic dendritic cells.
- Publisher
- MACMILLAN MAGAZINES LTD
- Keywords
- HEMATOPOIETIC STEM-CELLS; LANGERHANS CELLS; BONE-MARROW; MOUSE
- Publisher's Version
- https://doi.org/10.1038/362761a0
- Terms of Use/Rights Notice
- Refer to copyright notice on published article.
Creation Date: 1993-04-22 12:00:00