DEVELOPMENTAL REGULATION OF NEURAL RESPONSE TO FGF-1 AND FGF-2 BY HEPARAN-SULFATE PROTEOGLYCAN

Author(s): Nurcombe, V; Ford, MD; WILDSCHUT, JA; Bartlett, PF;
Details: Publication Year 1993-04-02,Volume 260,Issue #5104,Page 103-106
Journal Title: SCIENCE
Publication Type: Journal Article
Abstract: Murine neural precursor cells and cell lines derived from them are stimulated by members of the heparin-binding fibroblast growth factor (FGF) family. The activity of FGF is regulated by heparan sulfate proteoglycans (HSPGs), and this interaction is an essential prerequisite for the binding of growth factor to the signal transducing receptors. Messenger RNA for FGF-2 was detectable in the neuroepithelium at embryonic day 9, and the HSPGs produced by these cells at this time preferentially bound FGF-2. However, at embryonic day 11, when messenger RNA for FGF-1 was first detectable, there was a switch in the binding specificity of the HSPG to FGF-1. Thus, a single species of HSPG undergoes a rapid, tightly controlled change in growth factor-binding specificity concomitant with the temporal expression of the FGFs.
Publisher: AMER ASSOC ADVANCEMENT SCIENCE
Keywords: FIBROBLAST GROWTH-FACTOR; CENTRAL-NERVOUS-SYSTEM; CELL-SURFACE; BASEMENT-MEMBRANE; PRECURSOR CELLS; EXPRESSION; RECEPTOR; DIFFERENTIATION; NEURONS
Publisher's Version: https://doi.org/10.1126/science.7682010
Terms of Use/Rights Notice: Refer to copyright notice on published article.

Creation Date: 1993-04-02 12:00:00