OCT-2, ALTHOUGH NOT REQUIRED FOR EARLY B-CELL DEVELOPMENT, IS CRITICAL FOR LATER B-CELL MATURATION AND FOR POSTNATAL SURVIVAL
- Author(s)
- Corcoran, LM; KARVELAS, M; Nossal, GJV; YE, ZS; Jacks, T; Baltimore, D;
- Details
- Publication Year 1993-04,Volume 7,Issue #4,Page 570-582
- Journal Title
- GENES & DEVELOPMENT
- Publication Type
- Journal Article
- Abstract
- Oct-2, a POU homeo domain transcription factor, is believed to stimulate B-cell-restricted expression of immunoglobulin genes through binding sites in immunoglobulin gene promoters and enhancers. To determine whether Oct-2 is required for B-cell development or function, or has other developmental roles, the gene was disrupted by homologous recombination. Oct-2-/- mice develop normally but die within hours of birth for undetermined reasons. Mutants contain normal numbers of B-cell precursors but are somewhat deficient in IgM+ B cells. These B cells have a marked defect in their capacity to secrete immunoglobulin upon mitogenic stimulation in vitro. Thus, Oct-2 is not required for the generation of immunoglobulin-bearing B cells but is crucial for their maturation to immunoglobulin-secreting cells and for another undetermined organismal
- Publisher
- COLD SPRING HARBOR LAB PRESS
- Keywords
- HEAVY-CHAIN PROMOTER; OCTAMER DNA MOTIF; IMMUNOGLOBULIN GENE-TRANSCRIPTION; CONSERVED SEQUENCE; PROTEIN-BINDING; POU DOMAIN; STEM-CELLS; MONOCLONAL-ANTIBODY; LY-1 B; MOUSE
- Publisher's Version
- https://doi.org/10.1101/gad.7.4.570
- Terms of Use/Rights Notice
- Refer to copyright notice on published article.
Creation Date: 1993-04-01 12:00:00