3 DECADES OF T-OLOGY
- Author(s)
- Miller, JFAP;
- Details
- Publication Year 1990-11,Volume 16,Issue #3-4,Page 131-142
- Journal Title
- THYMUS
- Publication Type
- Journal Article
- Abstract
- Tremendous progress has been achieved in our understanding of thymus function in the last 3 decades. Distinct T cell subsets have been characterized and shown to have an essential role in initiating and in regulating a variety of immune responses. The ontogenetic events which lead to their intrathymic differentiation have been mapped and have allowed studies on the selection of the T cell repertoire. The major histocompatibility complex and associated antigenic peptides play a major role in T cell selection and antigen activation. The T cell receptor for antigen and the genes which code for it have recently been identified. Future studies should allow some insight into how to activate specific T cells more effectively for vaccination purposes and how to switch them off to induce tolerance to transplanted tissues.
- Publisher
- KLUWER ACADEMIC PUBL
- Keywords
- I HISTOCOMPATIBILITY ANTIGENS; PANCREATIC BETA-CELLS; TRANSGENIC MICE; IMMUNE-RESPONSE; EXPRESSION; TOLERANCE; RECEPTOR; THYMUS; LYMPHOCYTES; MOLECULES
- Terms of Use/Rights Notice
- Refer to copyright notice on published article.
Creation Date: 1990-11-01 12:00:00