ACTIVATION OF HUMAN LYMPHOCYTES-T BY LEISHMANIA LIPOPHOSPHOGLYCAN
Details
Publication Year 1991-02, Volume 33, Issue #2, Page 219-224
Journal Title
SCANDINAVIAN JOURNAL OF IMMUNOLOGY
Publication Type
Journal Article
Abstract
This study describes Leishmania antigen-induced activation of lymphocytes isolated from Kenyan donors, previously treated for visceral leishmaniasis, and from Danish and Kenyan controls. Peripheral blood mononuclear cells (PBMC) from cured Kala-Azar patients proliferated and produced Interferon-gamma in vitro in response to lipophosphoglycan (LPG) isolated from Leishmania major. The proliferative response was mainly due to activation of CD2-positive T cells. PBMC from controls did not respond to LPG, but to sonicates prepared from both L. major and L. donovani promastigotes. The surface glycoprotein GP 63 failed to activate PBMC from any of the donors tested. These results show that the individuals cured from visceral leishmaniasis had expanded T-cell clones recognizing LPG, conceivably as a result of Leishmania infection. The LPG preparation was without detectable protein contamination. Thus, the results suggest that human T lymphocytes can respond to glycolipid antigens.
Publisher
BLACKWELL SCIENCE LTD
Keywords
EXPERIMENTAL VISCERAL LEISHMANIASIS; CUTANEOUS LEISHMANIASIS; INTERFERON-GAMMA; IMMUNIZATION; MACROPHAGES; RECEPTOR; INTERLEUKIN-2; MONOCYTES; DONOVANI; CELLS
Rights Notice
Refer to copyright notice on published article.


Creation Date: 1991-02-01 12:00:00
Last Modified: 0001-01-01 12:00:00
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