REGULATION OF MHC MOLECULES ON MBP POSITIVE OLIGODENDROCYTES IN MICE BY IFN-GAMMA AND TNF-ALPHA
- Author(s)
- Turnley, AM; Miller, JFAP; Bartlett, PF;
- Details
- Publication Year 1991-02-11,Volume 123,Issue #1,Page 45-48
- Journal Title
- NEUROSCIENCE LETTERS
- Publication Type
- Journal Article
- Abstract
- The expression of class I and class II histocompatibility antigens by myelin basic protein (MBP)-positive oligodendrocytes, in response to exogenous cytokines, has been investigated in vitro. It has been found that interferon-gamma (IFN-gamma), although capable of class I induction, does not induce class II on oligodendrocytes. Furthermore, tumour necrosis factor-alpha (TNF-alpha), which was shown to induce class I MHC on other neural cells, failed to induce class I on oligodendrocytes. A combination of IFN-gamma and TNF-alpha also failed to facilitate the expression of class II antigens on oligodendrocytes, nor did it amplify the expression of class I seen with IFN-gamma alone. Thus it appears that MBP+ murine oligodendrocytes are refractory to class II induction, and express class I in response to IFN-gamma but not TNF-alpha. The differential regulation and class of MHC expression may have implications in terms of the initiation and targeting of immune responses directed toward the oligodendrocyte.
- Publisher
- ELSEVIER SCI IRELAND LTD
- Keywords
- TUMOR NECROSIS FACTOR; MYELIN BASIC-PROTEIN; IA ANTIGENS; INTERFERON-GAMMA; EXPRESSION; CELLS; BRAIN; ASTROCYTES; INDUCTION; H-2
- Publisher's Version
- https://doi.org/10.1016/0304-3940(91)90154-L
- Terms of Use/Rights Notice
- Refer to copyright notice on published article.
Creation Date: 1991-02-11 12:00:00