FACTORS PREDICTING RESIDUAL BETA-CELL FUNCTION IN THE 1ST YEAR AFTER DIAGNOSIS OF CHILDHOOD TYPE-1 DIABETES
- Author(s)
- Couper, JJ; HUDSON, I; Werther, GA; WARNE, GL; COURT, JM; Harrison, LC;
- Details
- Publication Year 1991,Volume 11,Issue #1,Page 9-16
- Journal Title
- DIABETES RESEARCH AND CLINICAL PRACTICE
- Publication Type
- Journal Article
- Abstract
- Twenty-five children aged 2-14 years (mean age 8.39 +/- 0.78 years) were studied prospectively during the first year after the diagnosis of type 1 diabetes. Of their clinical and metabolic features at diagnosis, only age showed a significant independent relationship with endogeneous C-peptide production during the first year. Age was correlated with higher values for basal and stimulated plasma C-peptide at 7-14 days after diagnosis, at 6 months and at 12 months. At diagnosis, age was also associated with a higher value for HbA1c and a lower prevalence of insulin antibodies. C-peptide production peaked at 3 months and thereafter declined. Mean HbA1c and insulin requirement were both minimal at 6 months. At diagnosis, there were significant inverse relationships between basal C-peptide production and both insulin dose and HbA1c and between stimulated C-peptide production and HbA1c. Basal and stimulated C-peptide production were inversely related to insulin dose at 6 and 12 months. Stimulated C-peptide was higher at 12 months in children retaining islet cell antibodies. These findings confirm the importance of age as a predictor of residual beta-cell function in type 1 diabetes and indicate that older children present clinically following a slower course of beta cell destruction.
- Publisher
- ELSEVIER SCI IRELAND LTD
- Keywords
- INSULIN-DEPENDENT DIABETICS; POST-INITIAL REMISSION; PLASMA C-PEPTIDE; CLINICAL-DIAGNOSIS; RECENT ONSET; CHILDREN; ANTIBODIES; MELLITUS; PREVALENCE; SECRETION
- Publisher's Version
- https://doi.org/10.1016/0168-8227(91)90135-Z
- Terms of Use/Rights Notice
- Refer to copyright notice on published article.
Creation Date: 1991-01-01 12:00:00