IMMUNIZATION OF OWL MONKEYS WITH THE RING-INFECTED ERYTHROCYTE SURFACE-ANTIGEN OF PLASMODIUM-FALCIPARUM
- Author(s)
- Collins, WE; Anders, RF; RUEBUSH, TK; Kemp, DJ; Woodrow, GC; CAMPBELL, GH; Brown, GV; Irving, DO; GOSS, N; FILIPSKI, VK; Coppel, RL; BRODERSON, JR; THOMAS, LM; Pye, D; SKINNER, JC; Wilson, C; STANFILL, PS; PROCELL, PM;
- Details
- Publication Year 1991-01,Volume 44,Issue #1,Page 34-41
- Journal Title
- AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE
- Publication Type
- Journal Article
- Abstract
- Aotus nancymai were immunized with the 4-mer, 8-mer, and 11-mer repeat peptides of the ring-infected erythrocyte surface antigen molecule of Plasmodium falciparum conjugated to diphtheria toxoid with muramyl dipeptide (MDP) as adjuvant. Immunization failed to induce protective immunity against the Uganda Palo Alto strain of P. falciparum as judged by maximum levels of parasitemia of immunized monkeys relative to those of controls. The fused polypeptide FPAg632, when combined with MDP, also failed to induce protective immunity. However, the maximum level of parasitemia and serologic response to the 11-mer peptide were inversely correlated. The safety of the use of MDP was evident.
- Publisher
- AMER SOC TROP MED & HYGIENE
- Keywords
- VIVAX
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- Refer to copyright notice on published article.
Creation Date: 1991-01-01 12:00:00