VARIANTS OF A LEISHMANIA SURFACE-ANTIGEN DERIVED FROM A MULTIGENIC FAMILY
- Author(s)
- Murray, PJ; SPITHILL, TW;
- Details
- Publication Year 1991-12-25,Volume 266,Issue #36,Page 24477-24484
- Journal Title
- JOURNAL OF BIOLOGICAL CHEMISTRY
- Publication Type
- Journal Article
- Abstract
- The promastigote surface antigen-2 (PSA-2) complex comprises a group of immunogenic surface antigens linked to the surface of the Leishmania major promastigote with glycosylphosphatidylinositol anchors. The L. major genome contains at least 14 PSA-2 genes on a 950-kilobase chromosome and comprising approximately 20% of the length of this chromosome. The sequence of three independent, but incomplete, PSA-2 cDNAs and one genomic fragment encoding a complete PSA-2 coding sequence were compared. PSA-2 genes encode polypeptides exhibiting 22-25aa tandem repeat elements, threonine-rich segments which vary between genes, a conserved COOH-terminal cysteine-rich region, and a conserved GPI anchor signal sequence. PSA-2 genes appear to be transcribed in a complex manner with multiple RNAs. The complex genomic organization of PSA-2 genes is present in other members of the genus suggesting that PSA-2 function is important for the biology of Leishmania.
- Publisher
- AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC
- Keywords
- TRYPANOSOMA-CRUZI; MEXICANA-AMAZONENSIS; GLYCOPROTEIN GP63; GENE; EXPRESSION; SEQUENCE; PROTEIN; LIPOPHOSPHOGLYCAN; PROMASTIGOTES; DONOVANI
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Creation Date: 1991-12-25 12:00:00