A CHROMOSOME-9 DELETION IN PLASMODIUM-FALCIPARUM RESULTS IN LOSS OF CYTOADHERENCE
- Kemp, DJ; Thompson, J; BARNES, DA; Triglia, T; Karamalis, F; PETERSEN, C; Brown, GV; Day, KP;
- Journal Title
- MEMORIAS DO INSTITUTO OSWALDO CRUZ
- Publication Type
- Journal Article
- Many lines of Plasmodium falciparum undergo a deletion of the right end of chromosome 9 during in vitro culture accompanied by loss of cytoadherence and gametocytogenesis. Selection of cytoadherent cells from a mixed population co-selects for those with an undeleted chromosome 9 and the selected cells produce gametocytes The deletion also results in loss of expression of PfEMP1, the putative cytoadherence ligand, suggesting that PfFMP1 or a regulatory gene controlling PfEMP1 expression and gametocytogenesis may be encoded in this region. We have isolated several markers for the deleted region and are currently using a YAC-P. falciparum library to investigate this region of the genome in detail.
- MEM INST OSWALDO CRUZ
- HUMAN CEREBRAL MALARIA; INFECTED ERYTHROCYTES; INVOLVE DELETIONS; P-FALCIPARUM; DIFFERENTIATION; POLYMORPHISMS; EXPRESSION; PARASITES; INVITRO; SURFACE
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Creation Date: 1992-01-01 12:00:00Last Modified: 0001-01-01 12:00:00