BCL-2 TRANSGENE INHIBITS T-CELL DEATH AND PERTURBS THYMIC SELF-CENSORSHIP
- Author(s)
- Strasser, A; Harris, AW; Cory, S;
- Details
- Publication Year 1991-11-29,Volume 67,Issue #5,Page 889-899
- Journal Title
- CELL
- Publication Type
- Journal Article
- Abstract
- Early death is the fate of most developing T lymphocytes. Because bcl-2 can promote cell survival, we tested its impact in mice expressing an E-mu-bcl-2 transgene within the T lymphoid compartment. The T cells showed remarkably sustained viability and some spontaneous differentiation in vitro. They also resisted killing by lymphotoxic agents. Although total T cell numbers and the rate of thymic involution were unaltered, the response to immunization was enhanced, consistent with reduced death of activated T cells. No T cells reactive with self-superantigens appeared in the lymph nodes, but an excess was found in the thymus. These observations, together with previous findings on B cells, suggest that modulated bcl-2 expression is a determinant of life and death in normal lymphocytes.
- Publisher
- CELL PRESS
- Keywords
- MAJOR HISTOCOMPATIBILITY COMPLEX; MONOCLONAL-ANTIBODY; DNA FRAGMENTATION; MEMBRANE PROTEIN; BETA-CHAIN; B-CELLS; RECEPTOR; EXPRESSION; ANTIGEN; TRANSLOCATION
- Publisher's Version
- https://doi.org/10.1016/0092-8674(91)90362-3
- Terms of Use/Rights Notice
- Refer to copyright notice on published article.
Creation Date: 1991-11-29 12:00:00