PERIPHERAL DELETION OF SELF-REACTIVE B-CELLS
- Author(s)
- RUSSELL, DM; DEMBIC, Z; Morahan, G; Miller, JFAP; BURKI, K; Nemazee, D;
- Details
- Publication Year 1991-11-28,Volume 354,Issue #6351,Page 308-311
- Journal Title
- NATURE
- Publication Type
- Journal Article
- Abstract
- B LYMPHOCYTES are key participants in the immune response because of their specificity, their ability to take up and present antigens to T cells, and their capacity to differentiate into antibody-secreting cells. To limit reactivity to self antigens, autospecific B cells can be functionally inactivated or deleted 1-4. Developing B cells that react with membrane antigens expressed in the bone, marrow are deleted from the peripheral lymphocyte pool 4-6. It is important to ascertain the fate of B cells that recognize membrane autoantigens expressed exclusively on peripheral tissues because B cells in the peripheral lymphoid organs are phenotypically and functionally distinct from bone-marrow B cells 7-9. Here we show that in immunoglobulin-transgenic mice, B cells specific for major histocompatibility complex class I antigen can be deleted if they encounter membrane-bound antigen at a post-bone-marrow stage of development. This deletion may be necessary to prevent organ-specific autoimmunity.
- Publisher
- MACMILLAN MAGAZINES LTD
- Keywords
- IMMUNOGLOBULIN-M; TRANSGENIC MICE; CLONAL DELETION; LYMPHOCYTES-B; T-CELL; TOLERANCE; SUSCEPTIBILITY; SUPPRESSION; EXPRESSION; ANTIGENS
- Publisher's Version
- https://doi.org/10.1038/354308a0
- Terms of Use/Rights Notice
- Refer to copyright notice on published article.
Creation Date: 1991-11-28 12:00:00