PRIMARY STRUCTURE OF A PLASMODIUM-FALCIPARUM RHOPTRY ANTIGEN
Author(s)
BROWN, HJ; Coppel, RL;
Details
Publication Year 1991-11,Volume 49,Issue #1,Page 99-110
Journal Title
MOLECULAR AND BIOCHEMICAL PARASITOLOGY
Publication Type
Journal Article
Abstract
The high-molecular-weight rhoptry complex of Plasmodium falciparum consists of 3 non-covalently associated polypeptides of 150, 135 and 105 kDa. We present the complete nucleotide sequence of the 105-kDa (RhopH3) component of this complex derived from analysis of genomic and cDNA clones. The genomic structure is unusually complex for P. falciparum, consisting of 7 exons including 2 mini-exons of 19 and 21 amino acids. The sequence lacks tandem repeats and is conserved among several parasite isolates, B cell epitopes that induce antibody responses during natural infection were mapped to five different regions of the polypeptide.
Publisher
ELSEVIER SCIENCE BV
Keywords
HUMAN MALARIA PARASITE; BETA-TUBULIN GENE; NUCLEOTIDE-SEQUENCE; MONOCLONAL-ANTIBODIES; MOLECULAR-CLONING; ALPHA-TUBULIN; RICH PROTEIN; MEROZOITES; EXPRESSION; COMPLEX
Terms of Use/Rights Notice
Refer to copyright notice on published article.


Creation Date: 1991-11-01 12:00:00
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