PRIMARY STRUCTURE OF A PLASMODIUM-FALCIPARUM RHOPTRY ANTIGEN
- Author(s)
- BROWN, HJ; Coppel, RL;
- Details
- Publication Year 1991-11,Volume 49,Issue #1,Page 99-110
- Journal Title
- MOLECULAR AND BIOCHEMICAL PARASITOLOGY
- Publication Type
- Journal Article
- Abstract
- The high-molecular-weight rhoptry complex of Plasmodium falciparum consists of 3 non-covalently associated polypeptides of 150, 135 and 105 kDa. We present the complete nucleotide sequence of the 105-kDa (RhopH3) component of this complex derived from analysis of genomic and cDNA clones. The genomic structure is unusually complex for P. falciparum, consisting of 7 exons including 2 mini-exons of 19 and 21 amino acids. The sequence lacks tandem repeats and is conserved among several parasite isolates, B cell epitopes that induce antibody responses during natural infection were mapped to five different regions of the polypeptide.
- Publisher
- ELSEVIER SCIENCE BV
- Keywords
- HUMAN MALARIA PARASITE; BETA-TUBULIN GENE; NUCLEOTIDE-SEQUENCE; MONOCLONAL-ANTIBODIES; MOLECULAR-CLONING; ALPHA-TUBULIN; RICH PROTEIN; MEROZOITES; EXPRESSION; COMPLEX
- Publisher's Version
- https://doi.org/10.1016/0166-6851(91)90133-Q
- Terms of Use/Rights Notice
- Refer to copyright notice on published article.
Creation Date: 1991-11-01 12:00:00