CD4+CD8+CD3HIGH THYMOCYTES APPEAR TRANSIENTLY DURING ONTOGENY - EVIDENCE FROM PHENOTYPIC AND FUNCTIONAL-STUDIES

Author(s): HUGO, P; Boyd, RL; WAANDERS, GA; Scollay, R;
Details: Publication Year 1991-11,Volume 21,Issue #11,Page 2655-2660
Journal Title: EUROPEAN JOURNAL OF IMMUNOLOGY
Publication Type: Journal Article
Abstract: During T cell development thymocyte subsets emerge in a defined order, reflective of their maturational stage. In this study we determined the timing of appearance of CD4+CD8+CD3high thymocytes during in vivo and in vitro embryonic development, and thymic reconstitution after cortisone treatment. In these models, CD4+CD8+CD3high cells followed CD4+CD8+CD3low and preceded mature CD4+CD8-CD3high/CD4-CD8+CD3high thymocytes, while cortisone resistance was first seen among CD4+CD8+CD3high cells. CD4+CD8+CD3high thymocytes were also shown to display a pattern of antigen receptor-mediated calcium influx intermediate between that induced in other CD4+CD8+ cells and mature thymocytes. These results are consistent with a precursor-progeny relationship between CD4+CD8+CD3low and CD4+CD8+CD3high thymocytes, the latter developing to mature thymocytes (Hugo, P. et al., Int. Immunol. 1991. 3: 265).
Publisher: VCH PUBLISHERS INC
Keywords: CD3/T-CELL RECEPTOR COMPLEX; T-CELLS; IMMATURE THYMOCYTES; NEGATIVE SELECTION; POSITIVE SELECTION; CD4+8+ THYMOCYTES; TCR EXPRESSION; THYMUS; ANTIGEN; DIFFERENTIATION
Publisher's Version: https://doi.org/10.1002/eji.1830211103
Terms of Use/Rights Notice: Refer to copyright notice on published article.

Creation Date: 1991-11-01 12:00:00