ENHANCED INSULIN-RECEPTOR TYROSINE KINASE-ACTIVITY ASSOCIATED WITH CHROMOSOMAL TRANSLOCATION (1-19) IN A PRE-B-CELL LEUKEMIA LINE
Details
Publication Year 1992-02-01,Volume 50,Issue #3,Page 500-504
Journal Title
INTERNATIONAL JOURNAL OF CANCER
Publication Type
Journal Article
Abstract
The gene for the insulin receptor has been assigned to chromosome 19 near the breakpoint of the translocation t(1;19) which occurs in 25% of pre-B-cell leukemias. Insulin receptors in a pre-B-cell leukemia cell line (ACV) with t(1;19) were found to have 2-fold higher affinity for insulin, 5-fold higher basal and insulin-stimulated beta-sub-unit autophosphorylation, and 2-fold higher basal and 4-fold higher insulin-stimulated beta-sub-unit kinase activity on the synthetic peptide poly(Glu,Tyr), compared to receptors in a B-cell line (ADD) with normal karyotype from the same patient. ACV cells had a novel 13-kb receptor mRNA species and expressed a DNA polymorphism localized to the tyrosine kinase domain of the receptor gene. These findings suggest that t(1;19) in the ACV cell may result in rearrangement of the insulin receptor gene and translation of a receptor with enhanced tyrosine kinase activity.
Publisher
WILEY-LISS
Keywords
LYMPHOBLASTIC-LEUKEMIA; GENE; EXPRESSION; ONCOGENES; PROTEIN; BREAKPOINT; BINDING; FAMILY; BCR
Terms of Use/Rights Notice
Refer to copyright notice on published article.


Creation Date: 1992-02-01 12:00:00
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