ADHESION MOLECULES ARE EXPRESSED IN THE HUMAN RETINA AND CHOROID
- Author(s)
- DUGUID, IGM; Boyd, AW; Mandel, TE;
- Journal Title
- CURRENT EYE RESEARCH
- Publication Type
- Journal Article
- Abstract
- Immunoperoxidase staining of samples of normal human retina and choroid was Performed to demonstrate selected adhesion molecules in vivo. Intercellular adhesion molecule-1 (ICAM-1), lymphocyte function-associated antigen-3 (LFA-3) and endothelial leucocyte adhesion molecule-1 (ELAM-1) were expressed on retinal vascular endothelium and ICAM-1 and ELAM-1 in the region of the external limiting membrane. The very late antigen-2 (VLA-2) was found around the retinal ganglion cells and in the inner and outer fibre layers. The endothelium on the choriocapillaris showed moderate staining of ICAM-1, and slight staining of LFA-3 and ELAM-1. The presence of these molecules in this distribution strongly suggests they have an important role in the pathogenesis of immunologically mediated ocular conditions.
- Publisher
- OXFORD UNIV PRESS UNITED KINGDOM
- Keywords
- MECHANISMS; LFA-1
- Publisher's Version
- https://doi.org/10.3109/02713689208999526
- Terms of Use/Rights Notice
- Refer to copyright notice on published article.
Creation Date: 1992-01-01 12:00:00