ANTIGENIC VARIATION IN PLASMODIUM-FALCIPARUM
- Author(s)
- Biggs, BA; GOOZE, L; Wycherley, K; WOLLISH, W; Southwell, B; LEECH, JH; Brown, GV;
- Details
- Publication Year 1991-10,Volume 88,Issue #20,Page 9171-9174
- Journal Title
- PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Publication Type
- Journal Article
- Abstract
- Antigenic variation of infectious organisms is a major factor in evasion of the host immune response. However, there has been no definitive demonstration of this phenomenon in the malaria parasite Plasmodium falciparum. In this study, cloned parasites were examined serologically and biochemically for the expression of erythrocyte surface antigens. A cloned line of P. falciparum gave rise to progeny that expressed antigenically distinct forms of an erythrocyte surface antigen but were otherwise identical. This demonstrates that antigenic differences on the surface of P. falciparum-infected erythrocytes can arise by antigenic variation of clonal parasite populations. The antigenic differences were shown to result from antigenic variation of the parasite-encoded protein, the P. falciparum erythrocyte membrane protein 1.
- Publisher
- NATL ACAD SCIENCES
- Keywords
- AMELANOTIC MELANOMA-CELLS; INFECTED ERYTHROCYTES; ENDOTHELIAL-CELLS; KNOWLESI MALARIA; VARIANT ANTIGEN; MOLECULAR-BASIS; CYTOADHERENCE; SURFACE; IDENTIFICATION; EXPRESSION
- Publisher's Version
- https://doi.org/10.1073/pnas.88.20.9171
- Terms of Use/Rights Notice
- Refer to copyright notice on published article.
Creation Date: 1991-10-01 12:00:00