B-CELL SELECTION AND TOLERANCE
- Author(s)
- Nossal, GJV;
- Details
- Publication Year 1991-04,Volume 3,Issue #2,Page 193-198
- Journal Title
- CURRENT OPINION IN IMMUNOLOGY
- Publication Type
- Journal Article
- Abstract
- The B-lymphocyte repertoire can be divided into a primary repertoire of virgin B cells and a secondary repertoire of antigenically experienced cells. Self-tolerance requires that neither of these repertoires contains potentially active cells capable of high-affinity, anti-self antibody production. Recent work has proven that both the primary and the secondary repertoire can be functionally purged, and this mechanism may involve failure of appearance of anti-self clonotypes (clonal abortion) or defects in activation (clonal anergy).
- Publisher
- CURRENT BIOLOGY LTD
- Keywords
- EPITOPE-SPECIFIC REGULATION; TRANSGENIC MICE; LYMPHOCYTES-B; CLONAL DELETION; SELF-TOLERANCE; ANTIBODY; INDUCTION; ANTIGEN; MATURATION; EXPRESSION
- Publisher's Version
- https://doi.org/10.1016/0952-7915(91)90049-7
- Terms of Use/Rights Notice
- Refer to copyright notice on published article.
Creation Date: 1991-04-01 12:00:00