CHARACTERIZATION OF IMMATURE CD4+CD8-CD3- THYMOCYTES
- Author(s)
- HUGO, P; WAANDERS, GA; Scollay, R; PETRIE, HT; Boyd, RL;
- Details
- Publication Year 1991-03,Volume 21,Issue #3,Page 835-838
- Journal Title
- EUROPEAN JOURNAL OF IMMUNOLOGY
- Publication Type
- Journal Article
- Abstract
- Previously we have described (Hugo, P. et al., Int. Immunol. 1990. 2: 209) an immature CD4+CD8-CD3- thymocyte subset which is thought to be the counterpart of the CD4-CD8+CD3- subset. In this study we show that the ontogeny of these two subsets is parallel in fetal thymic organ culture. Extensive phenotypic characterization of CD4+CD8-CD3- cells reveals that they closely resemble CD4-CD8+CD3- thymocytes being: HSA(high), Thy-1high, interleukin 2 receptor alpha chain negative, CD44-, H-2K +/-, CD5low, MEL-14low/intermediate, CD2+, LFA-1+ and MTS 35+. Finally, we show that the proportion of CD4+CD8-CD3- thymocytes is highly variable between mouse strains.
- Publisher
- VCH PUBLISHERS INC
- Keywords
- CELL-RECEPTOR EXPRESSION; MOUSE THYMOCYTES; DIFFERENTIATION; SUBSET; INTERMEDIATE; EVENTS; THYMUS
- Publisher's Version
- https://doi.org/10.1002/eji.1830210346
- Terms of Use/Rights Notice
- Refer to copyright notice on published article.
Creation Date: 1991-03-01 12:00:00