NOVEL ZINC FINGER GENE IMPLICATED AS MYC COLLABORATOR BY RETROVIRALLY ACCELERATED LYMPHOMAGENESIS IN E-MU-MYC TRANSGENIC MICE
- Author(s)
- Haupt, Y; Alexander, WS; BARRI, G; Klinken, SP; Adams, JM;
- Details
- Publication Year 1991-05-31,Volume 65,Issue #5,Page 753-763
- Journal Title
- CELL
- Publication Type
- Journal Article
- Abstract
- To search for genes that can collaborate with myc in lymphomagenesis, we exploited retroviral insertional mutagenesis in E-mu-myc transgenic mice. Moloney murine leukemia virus accelerated development of B lymphoid tumors. Three quarters contained a provirus within the known pim-1 or pim-2 loci, new loci bmi-1 and emi-1, or combinations of these. bmi-1 insertions predominated, occurring in half the tumors, and resulted in elevated bmi-1 mRNA levels. Significantly, the bmi-1 gene, which is expressed in diverse normal cells, encodes a Cys/His metal-binding motif (C3HC4) that resembles those in several DNA-binding proteins and defines a new category of zinc finger gene. Thus, myc-induced lymphomagenesis can entail the concerted action of several genes, including the presumptive nuclear regulator bmi-1.
- Publisher
- CELL PRESS
- Keywords
- NUCLEIC-ACID-BINDING; SIMPLEX VIRUS TYPE-1; V-H-RAS; C-MYC; IMMUNOGLOBULIN ENHANCER; VIRAL INTEGRATION; B-CELLS; PROTEIN; EXPRESSION; ONCOGENE
- Publisher's Version
- https://doi.org/10.1016/0092-8674(91)90383-A
- Terms of Use/Rights Notice
- Refer to copyright notice on published article.
Creation Date: 1991-05-31 12:00:00