HELIX-LOOP-HELIX GENES TRANSLOCATED IN LYMPHOID LEUKEMIA
- Author(s)
- Visvader, J; Begley, CG;
- Details
- Publication Year 1991-09,Volume 16,Issue #9,Page 330-333
- Journal Title
- TRENDS IN BIOCHEMICAL SCIENCES
- Publication Type
- Journal Article
- Abstract
- A new class of DNA-binding proteins with a helix-loop-helix (HLH) structure has recently been described. Many of these transcriptional regulators are known to play a central role in cell-specification and differentiation processes. Four members of the HLH family are now implicated in the development of human lymphoid malignancies as a result of aberrant expression following chromosomal translocation events. This review focuses on two of these family members: SCL and LYL-1.
- Publisher
- ELSEVIER SCI LTD
- Keywords
- T-CELL LEUKEMIA; DNA-BINDING MOTIF; CHROMOSOMAL TRANSLOCATION; NUCLEAR-LOCALIZATION; NEGATIVE REGULATOR; TAL-1 GENE; SCL GENE; PROTEIN; DROSOPHILA; MYC
- Publisher's Version
- https://doi.org/10.1016/0968-0004(91)90137-K
- Terms of Use/Rights Notice
- Refer to copyright notice on published article.
Creation Date: 1991-09-01 12:00:00