FURTHER CHARACTERIZATION OF THE SCHISTOSOMA-JAPONICUM PROTEIN SJ23, A TARGET ANTIGEN OF AN IMMUNODIAGNOSTIC MONOCLONAL-ANTIBODY

Author(s): Davern, KM; Wright, MD; HERRMANN, VR; Mitchell, GF;
Details: Publication Year 1991-09,Volume 48,Issue #1,Page 67-76
Journal Title: MOLECULAR AND BIOCHEMICAL PARASITOLOGY
Publication Type: Journal Article
Abstract: Sj23, the 23-kDa target antigen in Schistosoma japonicum adult worms of the hybridoma monoclonal antibody (mAb) I-134, has been identified and cloned from cDNA libraries. mAb 1-134 has been successfully used in immunodiagnostic assays to detect S. japonicum infection in Philippine patients. Sequence analysis has shown that Sj23 is the homologue, with 84% amino acid identity, of Sm23, a 23-kDa molecule from S. mansoni worms previously described from our laboratory. The domain structures of Sj23 and Sm23 are strikingly similar to the human membrane proteins ME491, CD37, CD53 and TAPA-1, which may suggest a functional role for the schistosome molecules in cellular proliferation.
Publisher: ELSEVIER SCIENCE BV
Keywords: INTEGRAL MEMBRANE-PROTEIN; HYBRIDOMA ANTIBODY; 129/J MICE; MANSONI; ELECTROPHORESIS; INFECTION; FRAGMENTS; WORMS; CD37
Publisher's Version: https://doi.org/10.1016/0166-6851(91)90165-3
Terms of Use/Rights Notice: Refer to copyright notice on published article.

Creation Date: 1991-09-01 12:00:00