IL-5 and Rp105 signaling defects in B cells from commonly used 129 mouse substrains
- Author(s)
- Corcoran, LM; Metcalf, D;
- Details
- Publication Year 1999-12-01,Volume 163,Issue #11,Page 5836-5842
- Journal Title
- JOURNAL OF IMMUNOLOGY
- Publication Type
- Journal Article
- Abstract
- The use of 129 strain-derived embryonic stem cell lines for targeted gene mutation in mice has led directly to an expanded use of this inbred strain worldwide, It has been noted, however, that the 129 genetic background can make a significant contribution to the severity of a mutant phenotype, In this study, we reveal a specific defect in the IL-5 and Rp105 responses of B lymphocytes from Cure widely used 129 mouse substrains, The response to stimulation through surface IgM is also diminished, although to a lesser degree, in these mice, The lesion appears to reduce significantly the expression of the alpha-chain of the IL-5R, but may also influence events downstream of the LL-SR. This phenotype displays a codominant inheritance pattern, and is accompanied by a variable but significant depression of peritoneal B-l cell numbers in 50% of the mice.
- Publisher
- AMER ASSOC IMMUNOLOGISTS
- Keywords
- LINKED IMMUNODEFICIENT MICE; TYROSINE PHOSPHORYLATION; BRUTON TYROSINE; CD38 LIGATION; INTERLEUKIN-5; RESPONSES; MUTATION; PROLIFERATION; MATURATION; ACTIVATION
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- Refer to copyright notice on published article.
Creation Date: 1999-12-01 12:00:00