AVIDITY FOR ANTIGEN CAN INFLUENCE THE HELPER DEPENDENCE OF CD8+ T-LYMPHOCYTES
- Author(s)
- Heath, WR; KJERNIELSEN, L; Hoffmann, MW;
- Details
- Publication Year 1993-12-01,Volume 151,Issue #11,Page 5993-6001
- Journal Title
- JOURNAL OF IMMUNOLOGY
- Publication Type
- Journal Article
- Abstract
- To examine the influence of avidity on the helper dependence of CD8+ T cells, purified CD8+ T cells from transgenic mice expressing a TCR specific for H-2K(b) were tested for their responsiveness to spleen cells expressing different densities of H-2K(b). High avidity interactions resulted in the induction of strong proliferative responses by purified CD8+ T cells. These cells synthesized their own IL-2 and IL-2R. By contrast, low avidity interactions failed to induce proliferation or detectable IL-2 synthesis, although IL-2R were induced and addition of rIL-2 induced a proliferative response. These results are consistent with a model in which TCR avidity for Ag can determine the helper dependence of a CD8+ T cell.
- Publisher
- AMER ASSOC IMMUNOLOGISTS
- Keywords
- CLASS-I MHC; CELL SUBSETS; MONOCLONAL-ANTIBODIES; RESPONSES; INVIVO; INTERLEUKIN-2; GENERATION; INDUCTION; TOLERANCE; MECHANISM
- Terms of Use/Rights Notice
- Refer to copyright notice on published article.
Creation Date: 1993-12-01 12:00:00