DAN is a secreted glycoprotein related to Xenopus cerberus

Stanley, E; Biben, C; Kotecha, S; Fabri, L; Tajbakhsh, S; Wang, CC; Hatzistavrou, T; Roberts, B; Drinkwater, C; Lah, M; Buckingham, M; Hilton, D; Nash, A; Mohun, T; Harvey, RP

Author(s): Stanley, E; Biben, C; Kotecha, S; Fabri, L; Tajbakhsh, S; Wang, CC; Hatzistavrou, T; Roberts, B; Drinkwater, C; Lah, M; Buckingham, M; Hilton, D; Nash, A; Mohun, T; Harvey, RP;
Details: Publication Year 1998-10,Volume 77,Issue #2,Page 173-184
Journal Title: MECHANISMS OF DEVELOPMENT
Publication Type: Journal Article
Abstract: We report that DAN, a potential cell cycle regulator and tumour suppressor, is a secreted glycoprotein related to Xenopus cerberus. DAN, cerberus, its mouse relative Cer-1/cer-1/Cerberus-like/Cerr1, and the recently described factor DRM/Gremlin, appear to be members of the cystine knot superfamily, which includes TGF beta s and BMPs. Like cerberus and mCer-1, DAN induced cement glands as well as markers of anterior neural tissue and endoderm in Xenopus animal cap assays, features of BMP signalling blockade. During mouse embryogenesis, Dan was expressed from E8.5 in cranial mesenchyme and somites, then later in limb and facial mesenchyme. The pattern in somites was highly dynamic, with transcripts initially localized to the caudal half of the nascent epithelial somite, then, after maturation, to sclerotomal cells adjacent to the neural tube. Dan was also expressed in the developing myotome. The expression domains include sites in which BMP inhibition is known to be important for development. Thus, DAN appears to be a secreted factor belonging to the cystine knot superfamily, and one of a growing number of antagonists acting to modulate BMP signalling during development. (C) 1998 Elsevier Science ireland Ltd. All rights reserved.
Publisher: ELSEVIER SCIENCE BV
Keywords: MUSCLE PROGENITOR CELLS; BONE MORPHOGENETIC PROTEINS; TUMOR-SUPPRESSIVE ACTIVITY; 3Y1 RAT FIBROBLASTS; NORRIE DISEASE; GENE-PRODUCT; NUCLEOTIDE-SEQUENCE; SPEMANN ORGANIZER; TRANSFORMED-CELLS; MOLECULAR-CLONING
Publisher's Version: https://doi.org/10.1016/S0925-4773(98)00139-7
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Creation Date: 1998-10-01 12:00:00