Vaccination with recombinant Parasite Surface Antigen 2 from Leishmania major induces a Th1 type of immune response but does not protect against infection
- Author(s)
- Sjolander, A; Baldwin, TM; Curtis, JM; Bengtsson, KL; Handman, E;
- Details
- Publication Year 1998-12,Volume 16,Issue #20,Page 2077-2084
- Journal Title
- VACCINE
- Publication Type
- Journal Article
- Abstract
- Vaccination with the native Parasite Surface Antigen 2 of Leishmania major with Corynebacterium parvum as adjuvant protects mice from leishmaniasis through a Th1 mediated response. Here we show that vaccination with a recombinant form of this protein, purified from Escherichia coli and administered in iscoms or with C. parvum as adjuvant, does not induce protective immunity despite the induction of Th1 responses. The results suggest that protective immunity depends on the ability of the vaccinating antigen to induce Th1-like T cells with ability to be recalled by infection, Therefore, the conformation of antigens may play a more major role fop the induction of T cell mediated immunity than originally considered. (C) 1998 Elsevier Science Ltd. All rights reserved.
- Publisher
- ELSEVIER SCI LTD
- Keywords
- PROMASTIGOTE SURFACE-ANTIGEN-2; IMMUNOSTIMULATING COMPLEXES; CUTANEOUS LEISHMANIASIS; MURINE LEISHMANIASIS; ADJUVANT ACTIVITY; INTERFERON-GAMMA; BALB/C MICE; ISCOMS; INTERLEUKIN-4; EXPRESSION
- Publisher's Version
- https://doi.org/10.1016/S0264-410X(98)00075-9
- Terms of Use/Rights Notice
- Refer to copyright notice on published article.
Creation Date: 1998-12-01 12:00:00