Mechanisms of beta cell death in diabetes: A minor role for CD95
- Author(s)
- Allison, J; Strasser, A;
- Details
- Publication Year 1998-11-10,Volume 95,Issue #23,Page 13818-13822
- Journal Title
- PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Publication Type
- Journal Article
- Abstract
- Insulin-dependent diabetes mellitus is an autoimmune disease, under polygenic control, manifested only when >90% of the insulin-producing beta cells are destroyed. Although the disease is T cell mediated, the demise of the beta cell results from a number of different insults from the immune system. It has been proposed that foremost amongst these effector mechanisms is CD95 Ligand-induced beta cell death. Using the nonobese diabetic lpr mouse as a model system, we have found, to the contrary, that CD95 plays only a minor role in the death of beta cells. Islet grafts from nonobese diabetic mice that carry the lpr mutation and therefore lack CD95 were protected only marginally from immune attack when grafted into diabetic mice. An explanation to reconcile these differing results is provided.
- Publisher
- NATL ACAD SCIENCES
- Keywords
- VS-HOST DISEASE; CD8+ T-CELLS; FAS LIGAND; FLOW-CYTOMETRY; NOD MICE; APOPTOSIS; DESTRUCTION; MELLITUS; MOUSE; EXPRESSION
- Publisher's Version
- https://doi.org/10.1073/pnas.95.23.13818
- Terms of Use/Rights Notice
- Refer to copyright notice on published article.
Creation Date: 1998-11-10 12:00:00