Structure and chromosomal mapping of the TNF-alpha inducible endothelial protein 1 (Edp1) gene in the mouse
- Author(s)
- Swift, S; Blackburn, C; Morahan, G; Ashworth, A;
- Details
- Publication Year 1998-11-08,Volume 1442,Issue #2-3,Page 394-398
- Journal Title
- BIOCHIMICA ET BIOPHYSICA ACTA-GENE STRUCTURE AND EXPRESSION
- Publication Type
- Journal Article
- Abstract
- EDP1 was identified as a human gene activated transcriptionally by tumour necrosis factor ex in endothelial cells. Here we have characterised the mouse Edp1 gene. We show that the gene encodes a highly conserved protein and describe its intron/exon structure. The presence of related genes in the sequence databases suggests that Edp1 is part of a gene family. Fine mapping of the gene in the mouse genome indicates that, as expected from its location on human chromosome 17, the mouse Edp1 gene maps to mouse chromosome 11. However, surprisingly, the gene does not map to the expected region of mouse chromosome 11 suggesting that a change in the order of genes has occurred within a conserved linkage group. (C) 1998 Elsevier Science B.V. All rights reserved.
- Publisher
- ELSEVIER SCIENCE BV
- Keywords
- RESPONSE GENE; ENCODES
- Publisher's Version
- https://doi.org/10.1016/S0167-4781(98)00180-8
- Terms of Use/Rights Notice
- Refer to copyright notice on published article.
Creation Date: 1998-11-08 12:00:00