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Showing results for: AUTHOR - De Nardo, D
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TDP-43 triggers mitochondrial DNA release via mPTP to activate cGAS/STING in ALS
Cell - 2020-10-03
Yu, CH; Davidson, S; Harapas, CR; Hilton, JB; Mlodzianoski, MJ; Laohamonthonkul, P; Louis, C; Low, RRJ; Moecking, J; De Nardo, D; Balka, KR; Calleja, DJ; Moghaddas, F; Ni, E; McLean, CA; Samson, AL; Tyebji, S; Tonkin, CJ; Bye, CR; Turner, BJ; Pepin, G; Gantier, MP; Rogers, KL; McArthur, K; Crouch, PJ; Masters, SL
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STAT3 serine phosphorylation is required for TLR4 metabolic reprogramming and IL-1beta expression
Nature Communications - 2020-07-30
Balic, JJ; Albargy, H; Luu, K; Kirby, FJ; Jayasekara, WSN; Mansell, F; Garama, DJ; De Nardo, D; Baschuk, N; Louis, C; Humphries, F; Fitzgerald, K; Latz, E; Gough, DJ; Mansell, A
Link to Open Access at Publisher's Site
Flexible Usage and Interconnectivity of Diverse Cell Death Pathways Protect against Intracellular Infection
Immunity - 2020-07-19
Doerflinger, M; Deng, Y; Whitney, P; Salvamoser, R; Engel, S; Kueh, AJ; Tai, L; Bachem, A; Gressier, E; Geoghegan, ND; Wilcox, S; Rogers, KL; Garnham, AL; Dengler, MA; Bader, SM; Ebert, G; Pearson, JS; De Nardo, D; Wang, N; Yang, C; Pereira, M; Bryant, CE; Strugnell, RA; Vince, JE; Pellegrini, M; Strasser, A; Bedoui, S; Herold, MJ
Link to Open Access at Publisher's Site
TBK1 and IKKepsilon act redundantly to mediate STING-I-induced NF-kappaB responses in myeloid cells
Cell Reports - 2020-04-07
Balka, KR; Louis, C; Saunders, TL; Smith, AM; Calleja, DJ; D'Silva, DB; Moghaddas, F; Tailler, M; Lawlor, KE; Zhan, Y; Burns, CJ; Wicks, IP; Miner, JJ; Kile, BT; Masters, SL; De Nardo, D
Link to Open Access at Publisher's Site
Connexin-dependent transfer of cGAMP to phagocytes modulates antiviral responses
mBio - 2020-01-28
Pepin, G; De Nardo, D; Rootes, CL; Ullah, TR; Al-Asmari, SS; Balka, KR; Li, HM; Quinn, KM; Moghaddas, F; Chappaz, S; Kile, BT; MORAND, EF; Masters, SL; Stewart, CR; Williams, BRG; Gantier, MP
Link to Open Access at Publisher's Site
The mitochondrial apoptotic effectors BAX/BAK activate caspase-3 and -7 to trigger NLRP3 inflammasome and caspase-8 driven IL-1beta activation
Cell Reports - 2018-11-27
Vince, JE; De Nardo, D; Gao, W; Vince, AJ; Hall, C; McArthur, K; Simpson, D; Vijayaraj, S; Lindqvist, LM; Bouillet, P; Rizzacasa, MA; Man, SM; Silke, J; Masters, SL; Lessene, G; Huang, DCS; Gray, DHD; Kile, BT; Shao, F; Lawlor, KE
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Understanding early TLR signaling through the Myddosome
Journal of Leukocyte Biology - 2018-09-26
Balka, KR; De Nardo, D
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Interleukin 1 receptor-associated kinase 4 (IRAK4) plays a dual role in Myddosome formation and Toll-like receptor signalling
Journal of Biological Chemistry - 2018-09
De Nardo, D; Balka, KR; Cardona Gloria, Y; Rao, VR; Latz, E; Masters, SL
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Autoinflammatory mutation in NLRC4 reveals an LRR-LRR oligomerization interface
Journal of Allergy and Clinical Immunology - 2018-05-17
Moghaddas, F; Zeng, P; Zhang, Y; Schutzle, H; Brenner, S; Hofmann, SR; Berner, R; Zhao, Y; Lu, B; Chen, X; Zhang, L; Cheng, S; Winkler, S; Lehmberg, K; Canna, SW; Czabotar, PE; Wicks, IP; De Nardo, D; Hedrich, CM; Zeng, H; Masters, SL
Link to Open Access at Publisher's Site
Emerging concepts in innate immunity
Innate Immune Activation. Methods in Molecular Biology, vol 1714 - 2018
Pelka, K; De Nardo, D
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Immortalization of murine bone marrow-derived macrophages
Macrophages. Methods in Molecular Biology, vol 1784 - 2018
De Nardo, D; Kalvakolanu, DV; Latz, E
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A mutation outside the dimerization domain causing atypical STING-associated vasculopathy with onset in infancy
Frontiers in Immunology - 2018
Saldanha, RG; Balka, KR; Davidson, S; Wainstein, BK; Wong, M; Macintosh, R; Loo, CKC; Weber, MA; Kamath, V; Circa,; Aadry,; Moghaddas, F; De Nardo, D; Gray, PE; Masters, SL
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Generation of innate immune reporter cells using retroviral transduction
Methods Mol Biol - 2018
Gloria, YC; Latz, E; De Nardo, D
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A novel Pyrin-Associated Autoinflammation with Neutrophilic Dermatosis mutation further defines 14-3-3 binding of pyrin and distinction to Familial Mediterranean Fever
Annals of the Rheumatic Diseases - 2017-12
Moghaddas, F; Llamas, R; De Nardo, D; Martinez-Banaclocha, H; Martinez-Garcia, JJ; Mesa-Del-Castillo, P; Baker, PJ; Gargallo, V; Mensa-Vilaro, A; Canna, S; Wicks, IP; Pelegrin, P; Arostegui, JI; Masters, SL
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Posttranslational modification as a critical determinant of cytoplasmic innate immune recognition
Physiol Rev - 2017-07-01
Baker, PJ; De Nardo, D; Moghaddas, F; Tran, LS; Bachem, A; Nguyen, T; Hayman, T; Tye, H; Vince, JE; Bedoui, S; Ferrero, RL; Masters, SL
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Active MLKL triggers the NLRP3 inflammasome in a cell-intrinsic manner
Proceedings of the National Academy of Sciences of the United States of America - 2017-02-07
Conos, SA; Chen, KW; De Nardo, D; Hara, H; Whitehead, L; Nunez, G; Masters, SL; Murphy, JM; Schroder, K; Vaux, DL; Lawlor, KE; Lindqvist, LM; Vince, JE
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Activation of the innate immune receptors: guardians of the micro galaxy : activation and functions of the innate immune receptors
Advances in Experimental Medicine and Biology - 2017
De Nardo, D
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Cyclodextrin promotes atherosclerosis regression via macrophage reprogramming
Sci Transl Med - 2016-04-06
Zimmer, S; Grebe, A; Bakke, SS; Bode, N; Halvorsen, B; Ulas, T; Skjelland, M; De Nardo, D; Labzin, LI; Kerksiek, A; Hempel, C; Heneka, MT; Hawxhurst, V; Fitzgerald, ML; Trebicka, J; Bjorkhem, I; Gustafsson, JA; Westerterp, M; Tall, AR; Wright, SD; Espevik, T; Schultze, JL; Nickenig, G; Lutjohann, D; Latz, E
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Familial autoinflammation with neutrophilic dermatosis reveals a regulatory mechanism of pyrin activation
Sci Transl Med - 2016-03-30
Masters, SL; Lagou, V; Jeru, I; Baker, PJ; Van Eyck, L; Parry, DA; Lawless, D; De Nardo, D; Garcia-Perez, JE; Dagley, LF; Holley, CL; Dooley, J; Moghaddas, F; Pasciuto, E; Jeandel, PY; Sciot, R; Lyras, D; Webb, AI; Nicholson, SE; De Somer, L; van Nieuwenhove, E; Ruuth-Praz, J; Copin, B; Cochet, E; Medlej-Hashim, M; Megarbane, A; Schroder, K; Savic, S; Goris, A; Amselem, S; Wouters, C; Liston, A
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Comprehensive RNAi-based screening of human and mouse TLR pathways identifies species-specific preferences in signaling protein use
Sci Signal - 2016
Sun, J; Li, N; Oh, KS; Dutta, B; Vayttaden, SJ; Lin, B; Ebert, TS; De Nardo, D; Davis, J; Bagirzadeh, R; Lounsbury, NW; Pasare, C; Latz, E; Hornung, V; Fraser, ID
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Erratum to: Measuring NLR oligomerization II: Detection of ASC speck formation by confocal microscopy and immunofluorescence
Methods Mol Biol - 2016
Beilharz, M; De Nardo, D; Latz, E; Franklin, BS
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Measuring NLR oligomerization II: Detection of ASC speck formation by confocal microscopy and immunofluorescence
Methods Mol Biol - 2016
Beilharz, M; De Nardo, D; Latz, E; Franklin, BS
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ATF3 Is a key regulator of macrophage IFN responses
Journal of Immunology - 2015-09-28
Labzin, LI; Schmidt, SV; Masters, SL; Beyer, M; Krebs, W; Klee, K; Stahl, R; Lutjohann, D; Schultze, JL; Latz, E; De Nardo, D
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Aberrant actin depolymerization triggers the pyrin inflammasome and autoinflammatory disease that is dependent on IL-18, not IL-1beta
J Exp Med - 2015-06-01
Kim, ML; Chae, JJ; Park, YH; De Nardo, D; Stirzaker, RA; Ko, HJ; Tye, H; Cengia, L; DiRago, L; Metcalf, D; Roberts, AW; Kastner, DL; Lew, AM; Lyras, D; Kile, BT; Croker, BA; Masters, SL
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Toll-like receptors: Activation, signalling and transcriptional modulation
Cytokine - 2015-04-03
De Nardo, D
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