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Showing results for: AUTHOR - Lessene, G

Found: 66 results

BCL-XL inhibition by BH3-mimetic drugs induces apoptosis in models of Epstein-Barr virus-associated T/NK-cell lymphoma Blood Advances - 2020-10-13 Sejic, N; George, LC; Tierney, RJ; Chang, C; Kondrashova, O; MacKinnon, RN; Lan, P; Bell, AI; Lessene, G; Long, HM; Strasser, A; Shannon-Lowe, C; Kelly, GL
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Potent inhibition of necroptosis by simultaneously targeting multiple effectors of the pathway ACS Chemical Biology - 2020-09-22 Pierotti, CL; Tanzer, MC; Jacobsen, AV; Hildebrand, JM; GARNIER, JM; Sharma, P; Lucet, IS; Cowan, AD; Kersten, WJA; Luo, MX; Liang, LY; Fitzgibbon, C; Garnish, SE; Hempel, A; Nachbur, U; Huang, DCS; Czabotar, PE; Silke, J; van Delft, MF; Murphy, JM; Lessene, G
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Defining the susceptibility of colorectal cancers to BH3-mimetic compounds Cell Death & Disease - 2020-09-10 Luo, MJ; Palmieri, M; Riffkin, CD; Sakthianandeswaren, A; Djajawi, TM; Hirokawa, Y; Shuttleworth, V; Segal, DH; White, CA; Nhu, D; Lessene, G; Lee, M; Gibbs, P; Huang, DCS; Sieber, OM; Gong, JN
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Mechanism and inhibition of the papain-like protease, PLpro, of SARS-CoV-2 EMBO Journal - 2020-08-26 Klemm, T; Ebert, G; Calleja, DJ; Allison, CC; Richardson, LW; Bernardini, JP; Lu, BG; Kuchel, NW; Grohmann, C; Shibata, Y; Gan, ZY; Cooney, JP; Doerflinger, M; Au, AE; Blackmore, TR; van der Heden van Noort, GJ; Geurink, PP; Ovaa, H; Newman, J; Riboldi-Tunnicliffe, A; Czabotar, PE; Mitchell, JP; Feltham, R; Lechtenberg, BC; Lowes, KN; Dewson, G; Pellegrini, M; Lessene, G; Komander, D
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Cotargeting BCL-2 and MCL-1 in high-risk B-ALL Blood Advances - 2020-06-23 Moujalled, DM; Hanna, DT; Hediyeh-Zadeh, S; Pomilio, G; BROWN, L; Litalien, V; Bartolo, R; Fleming, S; Chanrion, M; Banquet, S; Maragno, AL; Kraus-Berthier, L; Schoumacher, M; Mullighan, CG; Georgiou, A; White, CA; Lessene, G; Huang, DCS; Roberts, AW; Geneste, O; Rasmussen, L; Davis, MJ; Ekert, PG; Wei, A; Ng, AP; Khaw, SL
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MLKL trafficking and accumulation at the plasma membrane control the kinetics and threshold for necroptosis Nature Communications - 2020-06-19 Samson, AL; Zhang, Y; Geoghegan, ND; Gavin, XJ; Davies, KA; Mlodzianoski, MJ; Whitehead, LW; Frank, D; Garnish, SE; Fitzgibbon, C; Hempel, A; Young, SN; Jacobsen, AV; Cawthorne, W; Petrie, EJ; Faux, MC; Shield-Artin, K; Lalaoui, N; Hildebrand, JM; Silke, J; Rogers, KL; Lessene, G; Hawkins, ED; Murphy, JM
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A small molecule interacts with VDAC2 to block mouse BAK-driven apoptosis Nature Chemical Biology - 2019-11 van Delft, MF; Chappaz, S; Khakham, Y; Bui, CT; Debrincat, MA; Lowes, KN; Brouwer, JM; Grohmann, C; Sharp, PP; Dagley, LF; Li, L; McArthur, K; Luo, MX; Chin, HS; Fairlie, WD; Lee, EF; Segal, D; Duflocq, S; Lessene, R; Bernard, S; Peilleron, L; Nguyen, T; Miles, C; Wan, SS; Lane, RM; Wardak, A; Lackovic, K; Colman, PM; Sandow, JJ; Webb, AI; Czabotar, PE; Dewson, G; Watson, KG; Huang, DCS; Lessene, G; Kile, BT
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Viral MLKL homologs subvert necroptotic cell death by sequestering cellular RIPK3 Cell Reports - 2019-09-24 Petrie, EJ; Sandow, JJ; Lehmann, WIL; Liang, LY; Coursier, D; Young, SN; Kersten, WJA; Fitzgibbon, C; Samson, AL; Jacobsen, AV; Lowes, KN; Au, AE; Jousset Sabroux, H; Lalaoui, N; Webb, AI; Lessene, G; Manning, G; Lucet, IS; Murphy, JM
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Structures of BCL-2 in complex with venetoclax reveal the molecular basis of resistance mutations Nature Communications - 2019-06-03 Birkinshaw, RW; Gong, JN; Luo, CS; Lio, D; White, CA; Anderson, MA; Blombery, P; Lessene, G; Majewski, IJ; Thijssen, R; Roberts, AW; Huang, DCS; Colman, PM; Czabotar, PE
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BH3-mimetic drugs: blazing the trail for new cancer medicines Cancer Cell - 2018-12-10 Merino, D; Kelly, GL; Lessene, G; Wei, AH; Roberts, AW; Strasser, A
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The mitochondrial apoptotic effectors BAX/BAK activate caspase-3 and -7 to trigger NLRP3 inflammasome and caspase-8 driven IL-1beta activation Cell Reports - 2018-11-27 Vince, JE; De Nardo, D; Gao, W; Vince, AJ; Hall, C; McArthur, K; Simpson, D; Vijayaraj, S; Lindqvist, LM; Bouillet, P; Rizzacasa, MA; Man, SM; Silke, J; Masters, SL; Lessene, G; Huang, DCS; Gray, DHD; Kile, BT; Shao, F; Lawlor, KE
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Humanized Mcl-1 mice enable accurate pre-clinical evaluation of MCL-1 inhibitors destined for clinical use Blood - 2018-10 Brennan, MS; Chang, C; Tai, L; Lessene, G; Strasser, A; Dewson, G; Kelly, GL; Herold, MJ
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Combining BH3-Mimetics to target both BCL-2 and MCL1 has potent activity in pre-clinical models of acute myeloid leukemia Leukemia - 2018-09-10 Moujalled, DM; Pomilio, G; Ghiurau, C; Ivey, A; Salmon, J; Rijal, S; Macraild, S; Zhang, L; Teh, TC; Tiong, IS; Lan, P; Chanrion, M; Claperon, A; Rocchetti, F; Zichi, A; Kraus-Berthier, L; Wang, Y; Halilovic, E; Morris, E; Colland, F; Segal, D; Huang, D; Roberts, AW; Maragno, AL; Lessene, G; Geneste, O; Wei, AH
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Conformational switching of the pseudokinase domain promotes human MLKL tetramerization and cell death by necroptosis Nature Communications - 2018-06-21 Petrie, EJ; Sandow, JJ; Jacobsen, AV; Smith, BJ; Griffin, MDW; Lucet, IS; Dai, W; Young, SN; Tanzer, MC; Wardak, A; Liang, LY; Cowan, AD; Hildebrand, JM; Kersten, WJA; Lessene, G; Silke, J; Czabotar, PE; Webb, AI; Murphy, JM
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BAK/BAX macropores facilitate mitochondrial herniation and mtDNA efflux during apoptosis Science - 2018-02-23 McArthur, K; Whitehead, LW; Heddleston, JM; Li, L; Padman, BS; Oorschot, V; Geoghegan, ND; Chappaz, S; Davidson, S; San Chin, H; Lane, RM; Dramicanin, M; Saunders, TL; Sugiana, C; Lessene, R; Osellame, LD; Chew, TL; Dewson, G; Lazarou, M; Ramm, G; Lessene, G; Ryan, MT; Rogers, KL; van Delft, MF; Kile, BT
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Enhancing venetoclax activity in acute myeloid leukemia by co-targeting MCL1 Leukemia - 2018-02 Teh, TC; Nguyen, NY; Moujalled, DM; Segal, D; Pomilio, G; Rijal, S; Jabbour, A; Cummins, K; Lackovic, K; Blombery, P; Thompson, E; Ekert, PG; Lessene, G; Glaser, SP; Huang, DCS; Roberts, AW; Guthridge, MA; Wei, AH
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Dual inhibition of BCL-XL and MCL-1 is required to induce tumour regression in lung squamous cell carcinomas sensitive to FGFR inhibition Oncogene - 2018 Weeden, CE; Ah-Cann, C; Holik, AZ; Pasquet, J; GARNIER, JM; Merino, D; Lessene, G; Asselin-Labat, ML
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The Synthesis of (–)-spiroleucettadine Synlett - 2018 Lamb, RA; Lessene, G; Hawkins, BC
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Conversion of Bim-BH3 from activator to inhibitor of Bak through structure-based design Molecular Cell - 2017-11-16 Brouwer, JM; Lan, P; Cowan, AD; Bernardini, JP; Birkinshaw, RW; van Delft, MF; Sleebs, BE; Robin, AY; Wardak, A; Tan, IK; Reljic, B; Lee, EF; Fairlie, WD; Call, MJ; Smith, BJ; Dewson, G; Lessene, G; Colman, PM; Czabotar, PE
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Analysis of Ca2+ mediated signaling regulating Toxoplasma infectivity reveals complex relationships between key molecules Cellular Microbiology - 2017-10-26 Stewart, RJ; Whitehead, L; Nijagal, B; Sleebs, BE; Lessene, G; McConville, MJ; Rogers, KL; Tonkin, CJ
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Total Synthesis of (-)-Spiroleucettadine Angew Chem Int Ed Engl - 2017-09-27 Hawkins, BC; Lamb, R; Aberle, N; Lucas, N; Lessene, G
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ATF3 repression of BCL-XL determines apoptotic sensitivity toHDAC inhibitors across tumour types Clinical Cancer Research - 2017-09-15 Chueh, AC; Tse, JW; Dickinson, M; Ioannidis, P; Jenkins, L; Togel, L; Tan, B; Luk, I; Davalos-Salas, M; Nightingale, R; Thompson, MR; Williams, BR; Lessene, G; Lee, EF; Fairlie, WD; Dhillon, AS; Mariadason, JM
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Synergistic action of the MCL-1 inhibitor S63845 with current therapies in preclinical models of triple-negative and HER2-amplified breast cancer Science Translational Medicine - 2017-08-02 Merino, D; Whittle, JR; Vaillant, F; Serrano, A; Gong, JN; Giner, G; Maragno, AL; Chanrion, M; Schneider, E; Pal, B; Li, X; Dewson, G; Grasel, J; Liu, K; Lalaoui, N; Segal, D; Herold, MJ; Huang, DCS; Smyth, GK; Geneste, O; Lessene, G; Visvader, JE; Lindeman, GJ
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The BH3-only proteins BIM and PUMA are not critical for the reticulocyte apoptosis caused by loss of the pro-survival protein BCL-XL Cell Death & Disease - 2017-07-06 Delbridge, AR; Aubrey, BJ; Hyland, C; Bernardini, JP; Di Rago, L; GARNIER, JM; Lessene, G; Strasser, A; Alexander, WS; Grabow, S
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Inhibition of hematopoietic cell kinase activity suppresses myeloid cell-mediated colon cancer progression Cancer Cell - 2017-04-10 Poh, AR; Love, CG; Masson, F; Preaudet, A; Tsui, C; Whitehead, L; Monard, S; Khakham, Y; Burstroem, L; Lessene, G; Sieber, O; Lowell, C; Putoczki, TL; O'Donoghue, RJ; Ernst, M
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