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Showing results for: AUTHOR - Puthalakath, H

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TREML4 receptor regulates inflammation and innate immune cell death during polymicrobial sepsis Nature Immunology - 2020-10-05 Nedeva, C; Menassa, J; Duan, M; Liu, C; Doerflinger, M; Kueh, AJ; Herold, MJ; Fonseka, P; Phan, TK; Faou, P; Rajapaksha, H; Chen, W; Hulett, MD; Puthalakath, H
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BCL-2 family protein BOK is a positive regulator of uridine metabolism in mammals Proceedings of the National Academy of Sciences of the United States of America - 2019-07-16 Srivastava, R; Cao, Z; Nedeva, C; Naim, S; Bachmann, D; Rabachini, T; Gangoda, L; Shahi, S; Glab, J; Menassa, J; Osellame, L; Nelson, T; Fernandez-Marrero, Y; Brown, F; Wei, A; Ke, F; O'Reilly, L; Doerflinger, M; Allison, C; Kueh, A; Ramsay, R; Smith, BJ; Mathivanan, S; Kaufmann, T; Puthalakath, H
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ROCK1 but not LIMK1 or PAK2 is a key regulator of apoptotic membrane blebbing and cell disassembly Cell Death and Differentiation - 2019-05-01 Tixeira, R; Phan, TK; Caruso, S; Shi, B; Atkin-Smith, GK; Nedeva, C; Chow, JDY; Puthalakath, H; Hulett, MD; Herold, MJ; Poon, IKH
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LMP2 immunoproteasome promotes lymphocyte survival by degrading apoptotic BH3-only proteins Immunology and Cell Biology - 2018-05-08 Zanker, D; Pang, K; Oveissi, S; Lu, C; Faou, P; Nowell, C; Mbogo, GW; Carotta, S; Quillici, C; Karupiah, G; Hibbs, M; Nutt, SL; Neeson, P; Puthalakath, H; Chen, W
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BH3-only proteins: the thorny end of the ER stress response Cell Death & Disease - 2017-06-22 Glab, JA; Doerflinger, M; Puthalakath, H
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DR5 and caspase-8 are dispensable in ER stress-induced apoptosis Cell Death and Differentiation - 2017 Glab, JA; Doerflinger, M; Nedeva, C; Jose, I; Mbogo, GW; Paton, JC; Paton, AW; Kueh, AJ; Herold, MJ; Huang, DC; Segal, D; Brumatti, G; Puthalakath, H
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Chemical chaperone TUDCA prevents apoptosis and improves survival during polymicrobial sepsis in mice Scientific Reports - 2016-10-03 Doerflinger, M; Glab, J; Nedeva, C; Jose, I; Lin, A; O'Reilly, L; Allison, C; Pellegrini, M; Hotchkiss, RS; Puthalakath, H
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Variola virus F1L is a Bcl-2-like protein that unlike its vaccinia virus counterpart inhibits apoptosis independent of Bim Cell Death Dis - 2015 Marshall, B; Puthalakath, H; Caria, S; Chugh, S; Doerflinger, M; Colman, PM; Kvansakul, M
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Loss of Prkar1a leads to Bcl-2 family protein induction and cachexia in mice. Cell Death and Differentiation - 2014-07-11 Gangoda, L; Doerflinger, M; Srivastava, R; Narayan, N; Edgington, LE; Orian, J; Hawkins, C; O'Reilly, LA; Gu, H; Bogyo, M; Ekert, P; Strasser, A; Puthalakath, H
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Evidence against upstream regulation of the unfolded protein response (UPR) by pro-apoptotic BIM and PUMA Cell Death Dis - 2014 Herold, MJ; O'Reilly, LA; Lin, A; Srivastava, R; Doerflinger, M; Bouillet, P; Strasser, A; Puthalakath, H
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Role of p53 in cAMP/PKA pathway mediated apoptosis. Apoptosis : an international journal on programmed cell death - 2013-12 Rahimi, A; Lee, YY; Abdella, H; Doerflinger, M; Gangoda, L; Srivastava, R; Xiao, K; Ekert, PG; Puthalakath, H
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Hoxb8 regulates expression of microRNAs to control cell death and differentiation CELL DEATH AND DIFFERENTIATION - 2013-10 Salmanidis, M; Brumatti, G; Narayan, N; Green, BD; van den Bergen, JA; Sandow, JJ; Bert, AG; Silke, N; Sladic, R; Puthalakath, H; Rohrbeck, L; Okamoto, T; Bouillet, P; Herold, MJ; Goodall, GJ; Jabbour, AM; Ekert, PG
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CREB-binding protein (CBP) regulates beta-adrenoceptor (beta-AR) - mediated apoptosis CELL DEATH AND DIFFERENTIATION - 2013-07 Lee, YY; Moujalled, D; Doerflinger, M; Gangoda, L; Weston, R; Rahimi, A; de Alboran, I; Herold, M; Bouillet, P; Xu, Q; Gao, X; Du, XJ; Puthalakath, H
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Cre transgene results in global attenuation of the cAMP/PKA pathway CELL DEATH & DISEASE - 2012-08 Gangoda, L; Doerflinger, M; Lee, YY; Rahimi, A; Etemadi, N; Chau, D; Milla, L; O'Connor, L; Puthalakath, H
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Cyclic-AMP-dependent protein kinase A regulates apoptosis by stabilizing the BH3-only protein Bim EMBO REPORTS - 2011-01 Moujalled, D; Weston, R; Anderton, H; Ninnis, R; Goel, P; Coley, A; Huang, DCS; Wu, L; Strasser, A; Puthalakath, H
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LIPOPOLYSACCHARIDE PLUS GALACTOSAMINE-INDUCED FATAL HEPATITIS MEDIATED BY SECRETED TNF alpha REQUIRES CASPASE-8 AND THE TWO BH3-ONLY PROTEINS BID AND BIM ADVANCES IN TNF FAMILY RESEARCH - 2011-01-01 Kaufmann, T; Jost, PJ; Pellegrini, M; Puthalakath, H; Gugasyan, R; Gerondakis, S; Hakem, R; Bouillet, P; Mak, TW; Dixit, VM; Strasser, A
MEK/ERK-Mediated Phosphorylation of Bim Is Required to Ensure Survival of T and B Lymphocytes during Mitogenic Stimulation JOURNAL OF IMMUNOLOGY - 2009-07-01 O'Reilly, LA; Kruse, EA; Puthalakath, H; Kelly, PN; Kaufmann, T; Huang, DCS; Strasser, A
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Fatal Hepatitis Mediated by Tumor Necrosis Factor TNF alpha Requires Caspase-8 and Involves the BH3-Only Proteins Bid and Bim IMMUNITY - 2009-01-16 Kaufmann, T; Jost, PJ; Pellegrini, M; Puthalakath, H; Gugasyan, R; Gerondakis, S; Cretney, E; Smyth, MJ; Silke, J; Hakem, R; Bouillet, P; Mak, TW; Dixit, VM; Strasser, A
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To trigger apoptosis, Bak exposes its BH3 domain and homodimerizes via BH3 : Groove interactions MOLECULAR CELL - 2008-05-09 Dewson, G; Kratina, T; Sim, HW; Puthalakath, H; Adams, JM; Colman, PM; Kluck, RM
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Fold up or perish: unfolded protein response and chemotherapy CELL DEATH AND DIFFERENTIATION - 2008-02 Strasser, A; Puthalakath, H
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A novel BH3 ligand that selectively targets Mcl-1 reveals that apoptosis can proceed without Mcl-1 degradation JOURNAL OF CELL BIOLOGY - 2008-01-28 Lee, EF; Czabotar, PE; van Delft, MF; Michalak, EM; Boyle, MJ; Willis, SN; Puthalakath, H; Bouillet, P; Colman, PM; Huang, DCS; Fairlie, WD
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What do we know about the mechanisms of elimination of autoreactive T and B cells and what challenges remain IMMUNOLOGY AND CELL BIOLOGY - 2008-01 Strasser, A; Puthalakath, H; O'Reilly, LA; Bouillet, P
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Gefitinib-induced killing of NSCLC cell lines expressing mutant EGFR requires BIM and can be enhanced by BH3 mimetics PLOS MEDICINE - 2007-10 Cragg, MS; Kuroda, J; Puthalakath, H; Huang, DCS; Strasser, A
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Interleukin 15-mediated survival of natural killer cells is determined by interactions among Bim, Noxa and Mcl-1 NATURE IMMUNOLOGY - 2007-08 Huntington, ND; Puthalakath, H; Gunn, P; Naik, E; Michalak, EM; Smyth, MJ; Tabarias, H; Degli-Esposti, MA; Dewson, G; Willis, SN; Motoyama, N; Huang, DCS; Nutt, SL; Tarlinton, DM; Strasser, A
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ER stress triggers apoptosis by activating BH3-only protein Bim CELL - 2007-06-29 Puthalakath, H; O'Reilly, LA; Gunn, P; Lee, L; Kelly, PN; Huntington, ND; Hughes, PD; Michalak, EM; McKimm-Breschkin, J; Motoyama, N; Gotoh, T; Akira, S; Bouillet, P; Strasser, A
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