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Showing results for: AUTHOR - Roberts, AW

Found: 166 results

Therapeutic development and current uses of BCL-2 inhibition Hematology Am Soc Hematol Educ Program - 2020-12-04 Roberts, AW
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Immune recovery in patients with mantle cell lymphoma receiving long-term ibrutinib and venetoclax combination therapy Blood Adv - 2020-10-13 Davis, JE; Handunnetti, SM; Ludford-Menting, M; Sharpe, C; Blombery, P; Anderson, MA; Roberts, AW; Seymour, JF; Tam, CS; Ritchie, DS; Koldej, RM
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Zanubrutinib for the treatment of patients with Waldenstrom macroglobulinemia: three years of follow-up Blood - 2020-07-22 Trotman, J; Opat, S; Gottlieb, DJ; Simpson, D; Marlton, P; Cull, G; Munoz, J; Tedeschi, A; Roberts, AW; Seymour, JF; Atwal, SK; Yu, Y; Novotny, W; Holmgren, EB; Tan, Z; Hilger, J; Huang, J; Tam, C
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Chemotherapy and Venetoclax in Elderly Acute Myeloid Leukemia Trial (CAVEAT): A Phase Ib Dose-Escalation Study of Venetoclax Combined With Modified Intensive Chemotherapy J Clin Oncol - 2020-07-20 Chua, CC; Roberts, AW; Reynolds, J; Fong, CY; Ting, SB; Salmon, JM; Macraild, S; Ivey, A; Tiong, IS; Fleming, S; Brown, FC; Loo, S; Majewski, IJ; Bohlander, SK; Wei, AH
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Cotargeting BCL-2 and MCL-1 in high-risk B-ALL Blood Advances - 2020-06-23 Moujalled, DM; Hanna, DT; Hediyeh-Zadeh, S; Pomilio, G; BROWN, L; Litalien, V; Bartolo, R; Fleming, S; Chanrion, M; Banquet, S; Maragno, AL; Kraus-Berthier, L; Schoumacher, M; Mullighan, CG; Georgiou, A; White, CA; Lessene, G; Huang, DCS; Roberts, AW; Geneste, O; Rasmussen, L; Davis, MJ; Ekert, PG; Wei, A; Ng, AP; Khaw, SL
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BTK inhibitor therapy is effective in patients with CLL resistant to venetoclax Blood - 2020-04-03 Lin, VS; Lew, TE; Handunnetti, SM; Blombery, P; Nguyen, T; Westerman, DA; Kuss, BJ; Tam, C; Roberts, AW; Seymour, JF; Anderson, MA
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Targeting MCL-1 in hematologic malignancies: Rationale and progress Blood Reviews - 2020-02-21 Wei, AH; Roberts, AW; Spencer, A; Rosenberg, AS; Siegel, D; Walter, RB; Caenepeel, S; Hughes, P; McIver, Z; Mezzi, K; Morrow, PK; Stein, A
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Potent efficacy of MCL-1 inhibitor-based therapies in preclinical models of mantle cell lymphoma Oncogene - 2020-02 Dengler, MA; Teh, CE; Thijssen, R; Gangoda, L; Lan, P; Herold, MJ; Gray, DH; Kelly, GL; Roberts, AW; Adams, JM
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Deep profiling of apoptotic pathways with mass cytometry identifies a synergistic drug combination for killing myeloma cells Cell Death and Differentiation - 2020-01-27 Teh, CE; Gong, JN; Segal, D; Tan, T; Vandenberg, CJ; Fedele, PL; Low, MSY; Grigoriadis, G; Harrison, SJ; Strasser, A; Roberts, AW; Huang, DCS; Nolan, GP; Gray, DHD; Ko, ME
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Multiple BCL2 mutations co-occurring with Gly101Val emerge in chronic lymphocytic leukemia progression on venetoclax Blood - 2020-01-17 Blombery, P; Thompson, E; Nguyen, T; Birkinshaw, RW; Gong, J; Chen, X; McBean, M; Thijssen, R; Conway, T; Anderson, MA; Seymour, JF; Westerman, DA; Czabotar, PE; Huang, DCS; Roberts, AW
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Undetectable peripheral blood MRD should be the goal of venetoclax in CLL, but attainment plateaus after 24 months Blood Advances - 2020-01-14 Lew, TE; Anderson, MA; Lin, VS; Handunnetti, SM; Came, NA; Blombery, P; Westerman, DA; Wall, M; Tam, CS; Roberts, AW; Seymour, JF
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Molecular patterns of response and treatment failure after frontline venetoclax combinations in older patients with AML Blood - 2020-01-13 DiNardo, CD; Tiong, IS; Quaglieri, A; Macraild, S; Loghavi, S; Brown, FC; Thijssen, R; Pomilio, G; Ivey, A; Salmon, J; Glytsou, C; Fleming, SA; Zhang, Q; Ma, H; Patel, KP; Kornblau, SM; Xu, Z; Chua, CC; Chen, X; Blombery, P; Flensburg, C; Cummings, N; Aifantis, I; Kantarjian, H; Huang, DCS; Roberts, AW; Majewski, IJ; Konopleva, M; Wei, AH
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Ptpn6 inhibits caspase-8- and Ripk3/Mlkl-dependent inflammation Nature Immunology - 2019-12-09 Speir, M; Nowell, CJ; Chen, AA; O'Donnell, JA; Shamie, IS; Lakin, PR; D'Cruz, AA; Braun, RO; Babon, JJ; Lewis, RS; Bliss-Moreau, M; Shlomovitz, I; Wang, S; Cengia, LH; Stoica, AI; Hakem, R; Kelliher, MA; O'Reilly, LA; Patsiouras, H; Lawlor, KE; Weller, E; Lewis, NE; Roberts, AW; Gerlic, M; Croker, BA
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A phase 1b dose-escalation and expansion study of the BCL-2 inhibitor venetoclax combined with tamoxifen in ER and BCL-2-positive metastatic breast cancer Cancer Discovery - 2019-12-05 Lok, SW; Whittle, JR; Vaillant, F; Teh, CE; Lo, LL; Policheni, AN; Bergin, ART; Desai, J; Ftouni, S; Gandolfo, LC; Liew, D; Liu, HK; Mann, GB; Moodie, K; Murugasu, A; Pal, B; Roberts, AW; Rosenthal, MA; Shackleton, K; Silva, MJ; Siow, ZR; Smyth, GK; Taylor, L; Travers, A; Yeo, B; Yeung, MM; Zivanovic Bujak, A; Dawson, SJ; Gray, DHD; Visvader, JE; Lindeman, GJ
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Venetoclax in lymphoid malignancies: new insights, more to learn Cancer Cell - 2019-10-14 Thijssen, R; Roberts, AW
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Polyclonal heterogeneity: the new norm for secondary clinical resistance to targeted monotherapy in relapsed leukemia? Cancer Discovery - 2019-08 Wei, AH; Roberts, AW
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Phase 1 study of selective BTK inhibitor zanubrutinib in B-cell malignancies and safety and efficacy evaluation in CLL Blood - 2019-07-24 Tam, CSL; Trotman, J; Opat, S; Burger, JA; Cull, G; Gottlieb, DJ; Harrup, RA; Johnston, P; Marlton, P; Munoz, J; Seymour, JF; Simpson, DR; Tedeschi, A; Elstrom, R; Yu, Y; Tang, Z; Han, L; Huang, J; Novotny, W; Wang, L; Roberts, AW
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Efficacy of venetoclax in relapsed chronic lymphocytic leukemia is influenced by disease and response variables Blood - 2019-07 Roberts, AW; Ma, S; Kipps, TJ; Coutre, SE; Davids, MS; Eichhorst, B; Hallek, M; Byrd, JC; Humphrey, K; Zhou, L; Chyla, B; Nielsen, J; Potluri, J; Kim, SY; Verdugo, M; Stilgenbauer, S; Wierda, WG; Seymour, JF
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Characterization of a novel venetoclax resistance mutation (BCL2 Phe104Ile) observed in follicular lymphoma British Journal of Haematology - 2019-06-24 Blombery, P; Birkinshaw, RW; Nguyen, T; Gong, JN; Thompson, ER; Xu, Z; Westerman, DA; Czabotar, PE; Dickinson, M; Huang, DCS; Seymour, JF; Roberts, AW
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Structures of BCL-2 in complex with venetoclax reveal the molecular basis of resistance mutations Nature Communications - 2019-06-03 Birkinshaw, RW; Gong, JN; Luo, CS; Lio, D; White, CA; Anderson, MA; Blombery, P; Lessene, G; Majewski, IJ; Thijssen, R; Roberts, AW; Huang, DCS; Colman, PM; Czabotar, PE
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Acquisition of the recurrent Gly101Val mutation in BCL2 confers resistance to venetoclax in patients with progressive chronic lymphocytic leukemia Cancer Discovery - 2019-03 Blombery, P; Anderson, MA; Gong, JN; Thijssen, R; Birkinshaw, RW; Thompson, ER; Teh, CE; Nguyen, T; Xu, Z; Flensburg, C; Lew, TE; Majewski, IJ; Gray, DHD; Westerman, DA; Tam, CS; Seymour, JF; Czabotar, PE; Huang, DCS; Roberts, AW
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BH3-mimetic drugs: blazing the trail for new cancer medicines Cancer Cell - 2018-12-10 Merino, D; Kelly, GL; Lessene, G; Wei, AH; Roberts, AW; Strasser, A
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Dynamic molecular monitoring reveals that SWI-SNF mutations mediate resistance to ibrutinib plus venetoclax in mantle cell lymphoma Nature Medicine - 2018-11-19 Agarwal, R; Chan, YC; Tam, CS; Hunter, T; Vassiliadis, D; Teh, CE; Thijssen, R; Yeh, P; Wong, SQ; Ftouni, S; Lam, EYN; Anderson, MA; Pott, C; Gilan, O; Bell, CC; Knezevic, K; Blombery, P; Rayeroux, K; Zordan, A; Li, J; Huang, DCS; Wall, M; Seymour, JF; Gray, DHD; Roberts, AW; Dawson, MA; Dawson, SJ
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AMG 176, a selective MCL1 inhibitor, is effective in hematological cancer models alone and in combination with established therapies Cancer Discovery - 2018-09-25 Caenepeel, S; Brown, SP; Belmontes, B; Moody, G; Keegan, KS; Chui, D; Whittington, DA; Huang, X; Poppe, L; Cheng, AC; Cardozo, M; Houze, J; Li, Y; Lucas, B; Paras, NA; Wang, X; Taygerly, JP; Vimolratana, M; Zancanella, M; Zhu, L; Cajulis, E; Osgood, T; Sun, J; Damon, L; Egan, RK; Greninger, P; McClanaghan, JD; Gong, J; Moujalled, D; Pomilio, G; Beltran, P; Benes, CH; Roberts, AW; Huang, DCS; Wei, A; Canon, J; Coxon, A; Hughes, PE
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Combining BH3-Mimetics to target both BCL-2 and MCL1 has potent activity in pre-clinical models of acute myeloid leukemia Leukemia - 2018-09-10 Moujalled, DM; Pomilio, G; Ghiurau, C; Ivey, A; Salmon, J; Rijal, S; Macraild, S; Zhang, L; Teh, TC; Tiong, IS; Lan, P; Chanrion, M; Claperon, A; Rocchetti, F; Zichi, A; Kraus-Berthier, L; Wang, Y; Halilovic, E; Morris, E; Colland, F; Segal, D; Huang, D; Roberts, AW; Maragno, AL; Lessene, G; Geneste, O; Wei, AH
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