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Showing results for: AUTHOR - Sleebs, BE

Found: 48 results

Formaldehyde-activated WEHI-150 induces DNA interstrand crosslinks with unique structural features Bioorganic & Medicinal Chemistry - 2020-12-14 Pumuye, PP; Evison, BJ; Konda, SK; Collins, JG; Kelso, C; Medan, J; Sleebs, BE; Watson, K; Phillips, DR; Cutts, SM
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Retargeting azithromycin analogues to have dual-modality antimalarial activity BMC Biology - 2020-09-29 Burns, AL; Sleebs, BE; Siddiqui, G; De Paoli, AE; Anderson, D; Liffner, B; HARVEY, R; Beeson, JG; Creek, DJ; Goodman, CD; McFadden, GI; Wilson, DW
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Synthetic kavalactone analogues with increased potency and selective anthelmintic activity against arvae of Haemonchus contortus In Vitro Molecules - 2020-04-24 Herath, Hmpd; Taki, AC; Nguyen, N; Garcia-Bustos, J; Hofmann, A; Wang, T; Ma, G; Chang, BCH; Jabbar, A; Sleebs, BE; Gasser, RB
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Optimization of 5-substituted thiazolyl ureas and 6-substituted imidazopyridines as potential HIV-1 latency reversing agents European Journal of Medicinal Chemistry - 2020-03-20 Nguyen, W; Jacobson, J; Jarman, KE; Blackmore, TR; Sabroux, HJ; Lewin, SR; Purcell, DF; Sleebs, BE
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Screening the medicines for Malaria Venture Pathogen Box for invasion and egress inhibitors of the blood stage of Plasmodium falciparum reveals several inhibitory compounds International Journal for Parasitology - 2020-03-03 Dans, MG; Weiss, GE; Wilson, DW; Sleebs, BE; Crabb, BS; de Koning-Ward, TF; Gilson, PR
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Dual plasmepsin-targeting antimalarial agents disrupt multiple stages of the malaria parasite life cycle Cell Host & Microbe - 2020-02-27 Favuzza, P; de Lera Ruiz, M; Thompson, JK; Triglia, T; Ngo, A; Steel, RWJ; Vavrek, M; Christensen, J; Healer, J; Boyce, C; Guo, Z; Hu, M; Khan, T; Murgolo, N; Zhao, L; Penington, JS; Reaksudsan, K; Jarman, K; Dietrich, MH; Richardson, L; Guo, KY; Lopaticki, S; Tham, WH; Rottmann, M; Papenfuss, T; Robbins, JA; Boddey, JA; Sleebs, BE; Sabroux, HJ; McCauley, JA; Olsen, DB; Cowman, AF
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Inhibition of Plasmepsin V activity blocks Plasmodium falciparum gametocytogenesis and transmission to mosquitoes Cell Reports - 2019-12-17 Jennison, C; Lucantoni, L; O'Neill, MT; McConville, R; Erickson, SM; Cowman, AF; Sleebs, BE; Avery, VM; Boddey, JA
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The development process for discovery and clinical advancement of modern antimalarials Journal of Medicinal Chemistry - 2019-12 Ashton, TD; Devine, SM; Mohrle, JJ; Laleu, B; Burrows, JN; Charman, SA; Creek, DJ; Sleebs, BE
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An appraisal of natural products active against parasitic nematodes of animals Parasites & Vectors - 2019-06-17 Garcia-Bustos, JF; Sleebs, BE; Gasser, RB
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Identification of 5-substituted 2-acylaminothiazoles that activate Tat-mediated transcription in HIV-1 latency models Journal of Medicinal Chemistry - 2019-05-23 Nguyen, W; Jacobson, J; Jarman, KE; Jousset Sabroux, H; Harty, L; McMahon, J; Lewin, SR; Purcell, DF; Sleebs, BE
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Evaluation of 4-amino 2-anilinoquinazolines against Plasmodium and other apicomplexan parasites in vitro and in a P. falciparum humanized NOD-scid IL2Rgamma(null) mouse model of malaria Antimicrobial Agents and Chemotherapy - 2019-02 Gilson, PR; Nguyen, W; Poole, WA; Teixeira, JE; Thompson, JK; Guo, K; Stewart, RJ; Ashton, TD; White, KL; Sanz, LM; Gamo, FJ; Charman, SA; Wittlin, S; Duffy, J; Tonkin, CJ; Tham, WH; Crabb, BS; Cooke, BM; Huston, CD; Cowman, AF; Sleebs, BE
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Enhanced antimalarial activity of plasmepsin V inhibitors by modification of the P2 position of PEXEL peptidomimetics European Journal of Medicinal Chemistry - 2018-05-18 Nguyen, W; Hodder, AN; de Lezongard, RB; Czabotar, PE; Jarman, KE; O'Neill, MT; Thompson, JK; Jousset Sabroux, H; Cowman, AF; Boddey, JA; Sleebs, BE
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Conversion of Bim-BH3 from activator to inhibitor of Bak through structure-based design Molecular Cell - 2017-11-16 Brouwer, JM; Lan, P; Cowan, AD; Bernardini, JP; Birkinshaw, RW; van Delft, MF; Sleebs, BE; Robin, AY; Wardak, A; Tan, IK; Reljic, B; Lee, EF; Fairlie, WD; Call, MJ; Smith, BJ; Dewson, G; Lessene, G; Colman, PM; Czabotar, PE
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Analysis of Ca2+ mediated signaling regulating Toxoplasma infectivity reveals complex relationships between key molecules Cellular Microbiology - 2017-10-26 Stewart, RJ; Whitehead, L; Nijagal, B; Sleebs, BE; Lessene, G; McConville, MJ; Rogers, KL; Tonkin, CJ
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Screening the MMV Pathogen Box across multiple pathogens reclassifies starting points for open source drug discovery Antimicrob Agents Chemother - 2017-08-24 Duffy, S; Sykes, ML; Jones, AJ; Shelper, TB; Simpson, M; LANG, R; Poulsen, SA; Sleebs, BE; Avery, VM
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Mefloquine targets the Plasmodium falciparum 80S ribosome to inhibit protein synthesis Nat Microbiol - 2017-03-13 Wong, W; Bai, XC; Sleebs, BE; Triglia, T; Brown, A; Thompson, JK; Jackson, KE; Hanssen, E; Marapana, DS; Fernandez, IS; Ralph, SA; Cowman, AF; Scheres, SH; Baum, J
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Optimization of 2-Anilino 4-amino substituted Quinazolines into potent antimalarial agents with oral in vivo activity J Med Chem - 2017-02-09 Gilson, PR; Tan, C; Jarman, KE; Lowes, KN; Curtis, JM; Nguyen, W; Di Rago, AE; Bullen, HE; Prinz, B; Duffy, S; Baell, JB; Hutton, CA; Jousset Subroux, H; Crabb, BS; Avery, VM; Cowman, AF; Sleebs, BE
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Isolation and structural analysis of the covalent adduct formed between a bis-amino mitoxantrone analogue and DNA: a pathway to major-minor groove cross-linked adducts Org Biomol Chem - 2016-11-02 Konda, SK; Kelso, C; Medan, J; Sleebs, BE; Phillips, DR; Cutts, SM; Collins, JG
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Synthesis of amino heterocycle aspartyl protease inhibitors Org Biomol Chem - 2016-05-04 Chambers, RK; Khan, TA; Olsen, DB; Sleebs, BE
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Exploration of the P region of PEXEL peptidomimetics leads to a potent inhibitor of the Plasmodium protease, plasmepsin V Bioorg Med Chem - 2016-05-01 Gazdik, M; Jarman, KE; O'Neill, MT; Hodder, AN; Lowes, KN; Jousset Sabroux, H; Cowman, AF; Boddey, JA; Sleebs, BE
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An aspartyl protease defines a novel pathway for export of Toxoplasma proteins into the host cell Elife - 2015-11-18 Coffey, MJ; Sleebs, BE; Uboldi, AD; Garnham, AL; Franco, M; Marino, ND; Panas, MW; Ferguson, DJ; Enciso, M; O'Neill, MT; Lopaticki, S; Stewart, RJ; Dewson, G; Smyth, GK; Smith, BJ; Masters, SL; Boothroyd, JC; Boddey, JA; Tonkin, CJ
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Mitoxantrone, more than just another topoisomerase II poison Med Res Rev - 2015-08-19 Evison, BJ; Sleebs, BE; Watson, KG; Phillips, DR; Cutts, SM
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Structural basis for plasmepsin V inhibition that blocks export of malaria proteins to human erythrocytes Nat Struct Mol Biol - 2015-08 Hodder, AN; Sleebs, BE; Czabotar, PE; Gazdik, M; Xu, Y; O'Neill, MT; Lopaticki, S; Nebl, T; Triglia, T; Smith, BJ; Lowes, K; Boddey, JA; Cowman, AF
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HIV-1 and human PEG10 frameshift elements are functionally distinct and distinguished by novel small molecule modulators PLoS One - 2015 Cardno, TS; Shimaki, Y; Sleebs, BE; Lackovic, K; Parisot, JP; Moss, RM; Crowe-McAuliffe, C; Mathew, SF; Edgar, CD; Kleffmann, T; Tate, WP
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Macrolides rapidly inhibit red blood cell invasion by the human malaria parasite, Plasmodium falciparum BMC Biol - 2015 Wilson, DW; Goodman, CD; Sleebs, BE; Weiss, GE; de Jong, NW; Angrisano, F; Langer, C; Baum, J; Crabb, BS; Gilson, PR; McFadden, GI; Beeson, JG
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