Live and let die: insights into pseudoenzyme mechanisms from structure
Journal Title
Curr Opin Struct Biol
Publication Type
Journal Article
Abstract
Pseudoenzymes were first described more than 50 years ago, when it was recognised that a subset of proteins that are structurally homologous to active enzymes lack amino acids necessary for catalytic activity. Recently, interest in pseudoenzymes has surged as it has become apparent that they constitute approximately 10% of proteomes and perform essential metabolic and signalling functions that can be experimentally distinguished from catalytic outputs of enzymes. Here, we highlight recent structural studies of pseudoenzymes, which have revealed the molecular basis for roles as allosteric regulators of conventional enzymes, as molecular switches and integrators, as hubs for assembling protein complexes, and as competitors of substrate availability and holoenzyme assembly. As structural studies continue to illuminate pseudoenzyme molecular mechanisms, we anticipate that our knowledge of the breadth of their biological functions will expand in parallel.
Publisher
Elsevier
Research Division(s)
Cell Signalling And Cell Death
PubMed ID
28787627
Terms of Use/Rights Notice
Refer to copyright notice on published article.


Creation Date: 2017-08-30 02:22:20
Last Modified: 2018-12-21 09:54:32
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