The secret life of kinases: insights into non-catalytic signalling functions from pseudokinases
- Author(s)
- Jacobsen, AV; Murphy, JM;
- Details
- Publication Year 2017-06-15,Volume 45,Issue #3,Page 665-681
- Journal Title
- Biochem Soc Trans
- Publication Type
- Journal Article
- Abstract
- Over the past decade, our understanding of the mechanisms by which pseudokinases, which comprise approximately 10% of the human and mouse kinomes, mediate signal transduction has advanced rapidly with increasing structural, biochemical, cellular and genetic studies. Pseudokinases are the catalytically defective counterparts of conventional, active protein kinases and have been attributed functions as protein interaction domains acting variously as allosteric modulators of conventional protein kinases and other enzymes, as regulators of protein trafficking or localisation, as hubs to nucleate assembly of signalling complexes, and as transmembrane effectors of such functions. Here, by categorising mammalian pseudokinases based on their known functions, we illustrate the mechanistic diversity among these proteins, which can be viewed as a window into understanding the non-catalytic functions that can be exerted by conventional protein kinases.
- Publisher
- Portland Press
- Research Division(s)
- Cell Signalling And Cell Death
- PubMed ID
- 28620028
- Publisher's Version
- https://doi.org/10.1042/BST20160331
- NHMRC Grants
- NHMRC/1105754, NHMRC/1057905, NHMRC/1067289, NHMRC/1124735, NHMRC/1124737,
- Terms of Use/Rights Notice
- Refer to copyright notice on published article.
Creation Date: 2017-06-26 02:15:26
Last Modified: 2017-06-26 02:41:26