Relevance of necroptosis in cancer
- Author(s)
- Lalaoui, N; Brumatti, G;
- Details
- Publication Year 2017,Volume 95,Issue #2,Page 137-145
- Journal Title
- Immunology and Cell Biology
- Publication Type
- Journal Article
- Abstract
- Resistance to caspase-dependent apoptosis is often responsible for treatment failures in cancer. Finding novel therapeutic strategies that can activate alternative cell death programs appears to be appealing. Necroptosis is a form of programmed necrosis that occurs under caspase deficient conditions. This alternative form of cell death has recently emerged as a potential anti-cancer therapy that could overcome apoptosis resistance. A growing understanding of the molecular events triggering necroptosis helped to examine its implication in cancer development and to define new therapeutic strategies. Genetic and proteomic analysis suggest that necroptosis is deregulated in many cancers. Various preclinical and clinical compounds induced necroptosis and demonstrated significant therapeutic efficacy. Moreover, accumulating evidence has shown that necroptosis promotes anti-cancer immune response. A better knowledge of the cascade of events regulating necroptosis is expected to assess the feasibility of its therapeutic exploitation for cancer therapy. Immunology and Cell Biology accepted article preview online, 06 December 2016. doi:10.1038/icb.2016.120.
- Publisher
- Springer Nature
- Research Division(s)
- Cell Signalling And Cell Death
- PubMed ID
- 27922620
- Publisher's Version
- https://doi.org/10.1038/icb.2016.120
- Terms of Use/Rights Notice
- Refer to copyright notice on published article.
Creation Date: 2017-04-06 09:27:34
Last Modified: 2018-05-07 08:36:52