Deciphering clonality in aneuploid breast tumors using SNP array and sequencing data
Details
Publication Year 2014, Volume 15, Issue #9, Page 470
Journal Title
Genome Biol
Publication Type
Journal Article
Abstract
Intra-tumor heterogeneity concerns the existence of genetically different subclones within the same tumor. Single sample quantification of heterogeneity relies on precise determination of chromosomal copy numbers throughout the genome, and an assessment of whether identified mutation variant allele fractions match clonal or subclonal copy numbers. We discuss these issues using data from SNP arrays, whole exome sequencing and pathologist purity estimates on several breast cancers characterized by ERBB2 amplification. We show that chromosomal copy numbers can only be estimated from SNP array signals or sequencing depths for subclonal tumor samples with simple subclonal architectures under certain assumptions.
Publisher
BioMed Central
WEHI Research Division(s)
Bioinformatics
Open Access at Publisher's Site
http://genomebiology.com/content/15/9/470
Rights Notice
Refer to copyright notice on published article.


Creation Date: 2015-03-12 03:59:01
Last Modified: 2015-03-16 09:05:29
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