Androgen deprivation therapy promotes an obesity-like microenvironment in periprostatic fat
- Mangiola, S; Stuchbery, R; McCoy, PJ; Chow, K; Kurganovs, N; Kerger, M; Papenfuss, AT; Hovens, CM; Corcoran, NM;
Publication Year 2019-04-01, Volume 8, Issue #5, Page 518-527
- Journal Title
- Endocrine Connections
- Publication Type
- Journal Article
- Prostate cancer is a leading cause of morbidity and cancer-related death worldwide. Androgen deprivation therapy (ADT) is the cornerstone of management for advanced disease. The use of these therapies is associated with multiple side effects, including metabolic syndrome and truncal obesity. At the same time, obesity has been associated with both prostate cancer development and disease progression, linked to its effects on chronic inflammation at a tissue level. The connection between androgen deprivation therapy, obesity, inflammation, and prostate cancer progression is well-established in clinical settings; however, an understanding of the changes in adipose tissue at the molecular level induced by castration therapies is missing. Here we investigated the transcriptional changes in periprostatic fat tissue induced by profound androgen deprivation therapy in a group of patients with high-risk tumours compared to a matching untreated cohort. We find that the deprivation of androgen is associated with a pro-inflammatory and obesity-like adipose tissue microenvironment. This study suggests that the beneficial effect of therapies based on androgen deprivation may be partially counteracted by metabolic and inflammatory side effects in the adipose tissue surrounding the prostate.
- Bioscientifica Ltd
- WEHI Research Division(s)
- PubMed ID
- Publisher's Version
- Open Access at Publisher's Site
- Rights Notice
- Refer to copyright notice on published article.
Creation Date: 2019-04-11 12:23:45Last Modified: 2019-06-20 09:30:13