Studying X chromosome inactivation in the single-cell genomic era
- Author(s)
- Keniry, A; Blewitt, ME;
- Details
- Publication Year 2018-04-20,Volume 46,Issue #3,Page 577-586
- Journal Title
- Biochemical Society Transactions
- Publication Type
- Journal Article
- Abstract
- Single-cell genomics is set to revolutionise our understanding of how epigenetic silencing works; by studying specific epigenetic marks or chromatin conformations in single cells, it is possible to ask whether they cause transcriptional silencing or are instead a consequence of the silent state. Here, we review what single-cell genomics has revealed about X chromosome inactivation, perhaps the best characterised mammalian epigenetic process, highlighting the novel findings and important differences between mouse and human X inactivation uncovered through these studies. We consider what fundamental questions these techniques are set to answer in coming years and propose that X chromosome inactivation is an ideal model to study gene silencing by single-cell genomics as technical limitations are minimised through the co-analysis of hundreds of genes.
- Publisher
- Portland Press
- Research Division(s)
- Molecular Medicine
- PubMed ID
- 29678955
- Publisher's Version
- https://doi.org/10.1042/BST20170346
- NHMRC Grants
- NHMRC/1140976,
- Terms of Use/Rights Notice
- Refer to copyright notice on published article.
Creation Date: 2018-10-22 01:36:52
Last Modified: 2019-12-03 02:18:06