Cell death
- Author(s)
- Newton, K; Strasser, A; Kayagaki, N; Dixit, VM;
- Details
- Publication Year 2024-01-18,Volume 187,Issue #2,Page 235-256
- Journal Title
- Cell
- Abstract
- Cell death supports morphogenesis during development and homeostasis after birth by removing damaged or obsolete cells. It also curtails the spread of pathogens by eliminating infected cells. Cell death can be induced by the genetically programmed suicide mechanisms of apoptosis, necroptosis, and pyroptosis, or it can be a consequence of dysregulated metabolism, as in ferroptosis. Here, we review the signaling mechanisms underlying each cell-death pathway, discuss how impaired or excessive activation of the distinct cell-death processes can promote disease, and highlight existing and potential therapies for redressing imbalances in cell death in cancer and other diseases.
- Publisher
- Cell Press
- Keywords
- apoptosis; cell death; ferroptosis; necroptosis; pyroptosis
- Research Division(s)
- Blood Cells And Blood Cancer
- PubMed ID
- 38242081
- Publisher's Version
- https://doi.org/10.1016/j.cell.2023.11.044
- Open Access at Publisher's Site
https://doi.org/10.1016/j.cell.2023.11.044- Terms of Use/Rights Notice
- Refer to copyright notice on published article.
Creation Date: 2024-01-25 09:18:05
Last Modified: 2024-01-25 10:52:43